PLGA-based nanomedicine: history of advancement and development in clinical applications of multiple diseases

HO Alsaab, FD Alharbi, AS Alhibs, NB Alanazi… - Pharmaceutics, 2022 - mdpi.com
Research on the use of biodegradable polymers for drug delivery has been ongoing since
they were first used as bioresorbable surgical devices in the 1980s. For tissue engineering …

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

S Sun, Y Cui, B Yuan, M Dou, G Wang, H Xu… - … in bioengineering and …, 2023 - frontiersin.org
Drug delivery systems composed of osteogenic substances and biological materials are of
great significance in enhancing bone regeneration, and appropriate biological carriers are …

Reactive oxygen species (ROS): utilizing injectable antioxidative hydrogels and ROS-producing therapies to manage the double-edged sword

Z He, Q Xu, B Newland, R Foley, I Lara-Sáez… - Journal of Materials …, 2021 - pubs.rsc.org
Reactive oxygen species (ROS) are generated in cellular metabolism and are essential for
cellular signalling networks and physiological functions. However, the functions of ROS are …

[HTML][HTML] Polymer based sustained drug delivery to the ocular posterior segment: barriers and future opportunities for the treatment of neovascular pathologies

RA Alshaikh, C Waeber, KB Ryan - Advanced Drug Delivery Reviews, 2022 - Elsevier
There is an increasing momentum in research and pharmaceutical industry communities to
design sustained, non-invasive delivery systems to treat chronic neovascular ocular …

Functional thermoresponsive hydrogel molecule to material design for biomedical applications

S Pardeshi, F Damiri, M Zehravi, R Joshi, H Kapare… - Polymers, 2022 - mdpi.com
Temperature-induced, rapid changes in the viscosity and reproducible 3-D structure
formation makes thermos-sensitive hydrogels an ideal delivery system to act as a cell …

The recent advancement in the PLGA-based thermo-sensitive hydrogel for smart drug delivery

F Rahmani, R Atabaki, S Behrouzi… - International Journal of …, 2023 - Elsevier
To date, hydrogels have opened new prospects for potential applications for drug delivery.
The thermo-sensitive hydrogels have the great potential to provide more effective and …

Ocular delivery of therapeutic proteins: a review

DH Shastri, AC Silva, H Almeida - Pharmaceutics, 2023 - mdpi.com
Therapeutic proteins, including monoclonal antibodies, single chain variable fragment
(ScFv), crystallizable fragment (Fc), and fragment antigen binding (Fab), have accounted for …

Optimization of an injectable hydrogel depot system for the controlled release of retinal-targeted hybrid nanoparticles

I Ottonelli, A Bighinati, E Adani, F Loll, R Caraffi… - Pharmaceutics, 2022 - mdpi.com
A drawback in the development of treatments that can reach the retina is the presence of
barriers in the eye that restrain compounds from reaching the target. Intravitreal injections …

Neurotrophic factor-based pharmacological approaches in neurological disorders

M Alfonsetti, M d'Angelo, V Castelli - Neural regeneration …, 2023 - journals.lww.com
Aging is a physiological event dependent on multiple pathways that are linked to lifespan
and processes leading to cognitive decline. This process represents the major risk factor for …

Delivery systems in ocular retinopathies: the promising future of intravitreal hydrogels as sustained-release scaffolds

D Rafael, M Guerrero, A Marican, D Arango… - Pharmaceutics, 2023 - mdpi.com
Slow-release delivery systems are needed to ensure long-term sustained treatments for
retinal diseases such as age-related macular degeneration and diabetic retinopathy, which …