Value of preclinical systematic reviews and meta-analyses in pediatric research
O Romantsik, M Bank, JML Menon, A Malhotra… - Pediatric …, 2024 - nature.com
Similar to systematic reviews (SRs) in clinical fields, preclinical SRs address a specific
research area, furnishing information on current knowledge, possible gaps, and potential …
research area, furnishing information on current knowledge, possible gaps, and potential …
Weight of Evidence: Is an Animal Study Warranted? Assessments for Carcinogenicity, Drug Abuse Liability, and Pediatric Safety
T Ramani, RL Wange, TS Manetz… - International …, 2024 - journals.sagepub.com
Nonclinical safety studies are typically conducted to establish a toxicity profile of a new
pharmaceutical in clinical development. Such a profile may encompass multiple differing …
pharmaceutical in clinical development. Such a profile may encompass multiple differing …
Neuropathology evaluation in juvenile toxicity studies in rodents: comparison of developmental neurotoxicity studies for chemicals with juvenile animal studies for …
B Bolon, LA Dostal, RH Garman - Toxicologic Pathology, 2021 - journals.sagepub.com
The developmental neuropathology examination in juvenile toxicity studies depends on the
nature of the product candidate, its intended use, and the exposure scenario (eg, dose …
nature of the product candidate, its intended use, and the exposure scenario (eg, dose …
Juvenile Toxicology
V Vrolyk, C Tremblay, CA Picut - Drug Discovery and Evaluation: Safety …, 2024 - Springer
Juvenile toxicology encompasses the design, conduct, evaluation, and interpretation of
studies conducted in juvenile laboratory animals with the goal of assessing the safety of …
studies conducted in juvenile laboratory animals with the goal of assessing the safety of …
Regulatory perspectives on juvenile animal toxicologic pathology
DB Rao, AM Hoberman, PC Brown… - Toxicologic …, 2021 - journals.sagepub.com
The Society of Toxicologic Pathology's Annual Virtual Symposium (2021) included a session
on" Regulatory Perspectives on Juvenile Animal Toxicologic Pathology." The following …
on" Regulatory Perspectives on Juvenile Animal Toxicologic Pathology." The following …
The Role of Pathology in Evaluation of Reproductive, Developmental, and Juvenile Toxicity
CJ Bowman, WG Halpern - Haschek and Rousseaux's Handbook of …, 2022 - Elsevier
Drug and chemical product labels are expected to specifically address risks to special
populations such as pregnant women and children and are expected to highlight potential …
populations such as pregnant women and children and are expected to highlight potential …