The role of enriched environment in neural development and repair

Y Han, M Yuan, YS Guo, XY Shen, ZK Gao… - Frontiers in cellular …, 2022 - frontiersin.org
In addition to genetic information, environmental factors play an important role in the
structure and function of nervous system and the occurrence and development of some …

Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus

S Zocher, RW Overall, M Lesche, A Dahl… - Nature …, 2021 - nature.com
The decline of brain function during aging is associated with epigenetic changes, including
DNA methylation. Lifestyle interventions can improve brain function during aging, but their …

Longitudinal manganese‐enhanced magnetic resonance imaging of neural projections and activity

TW Uselman, CS Medina, HB Gray… - NMR in …, 2022 - Wiley Online Library
Manganese‐enhanced magnetic resonance imaging (MEMRI) holds exceptional promise
for preclinical studies of brain‐wide physiology in awake‐behaving animals. The objectives …

[HTML][HTML] Environmental enrichment leads to behavioral circadian shifts enhancing brain-wide functional connectivity between sensory cortices and eliciting increased …

FAM Manno, Z An, R Kumar, J Su, J Liu, EX Wu, J He… - Neuroimage, 2022 - Elsevier
Environmental enrichment induces widespread neuronal changes, but the initiation of the
cascade is unknown. We ascertained the critical period of divergence between …

Enhancement of astrocytic gap junctions Connexin43 coupling can improve long‐term isoflurane anesthesia–mediated brain network abnormalities and cognitive …

R Dong, P Lv, Y Han, L Jiang, Z Wang… - CNS Neuroscience …, 2022 - Wiley Online Library
Aim Astrocytes are connected by gap junctions Connexin43 (GJs‐Cx43) forming an
extensive intercellular network and maintain brain homeostasis. Perioperative …

[HTML][HTML] Enriched environment treatment promotes neural functional recovery together with microglia polarization and remyelination after cerebral ischemia in rats

Y Han, X Shen, Z Gao, P Han, X Bi - Brain Research Bulletin, 2024 - Elsevier
Background Microglia activation and oligodendrocyte maturation are critical for
remyelination after cerebral ischemia. Studies have shown that enriched environment (EE) …

Development and advancements in rodent MRI-based brain atlases

X Ma, Y Xing, R Zhai, Y Du, H Yan - Heliyon, 2024 - cell.com
Rodents, particularly mice and rats, are extensively utilized in fundamental neuroscience
research. Brain atlases have played a pivotal role in this field, evolving from traditional …

Dorsal dentate gyrus mediated enriched environment-induced anxiolytic and antidepressant effects in cortical infarcted mice

D Huang, Y Fan, J Zhang, Q Wang, M Ding, R Hou… - Experimental …, 2024 - Elsevier
Anxiety and depression are the most common mental health disorders worldwide, each
affecting around 30% stroke survivors. These complications not only affect the functional …

Phasic firing of dopaminergic neurons in the ventral tegmental area triggers peripheral immune responses

T Kayama, Y Ikegaya, T Sasaki - Scientific reports, 2022 - nature.com
Dopaminergic neurons in the ventral tegmental area (VTA) play a crucial role in the
processing of reward-related information. Recent studies with pharmacological …

Cholecystokinin receptor antagonist challenge elicits brain-wide functional connectome modulation with micronetwork hippocampal decreased calcium transients

FAM Manno, Z An, J Su, J Liu, J He, EX Wu… - Cerebral …, 2023 - academic.oup.com
The cortical distribution and functional role of cholecystokinin (CCK) are largely unknown.
Here, a CCK receptor antagonist challenge paradigm was developed to assess functional …