Patients with obesity have a high prevalence of nonalcoholic fatty liver disease (NAFLD),
representing a spectrum of simple steatosis to nonalcoholic steatohepatitis (NASH), without …

There is a wide variety of kinds of lipids, and complex structures which determine the
diversity and complexity of their functions. With the basic characteristic of water insolubility …

Growth hormone (GH) and insulin-like growth factor-1 (IGF-I) are pleiotropic hormones with
important roles in lifespan. They promote growth, anabolic actions, and body maintenance …

In the mid-1990s, interest in adipose tissue–until then generally regarded as a mere energy
reserve–was revived by the discovery of leptin. Since then numerous other cytokine-like …

It is well established that reproductive function is metabolically gated. However, the
mechanisms whereby energy stores and metabolic cues influence fertility are yet to be …

Growth hormone (GH), a master regulator of somatic growth, also regulates carbohydrate
and lipid metabolism via complex interactions with insulin and insulin-like growth factor-1 …

This article reviews the main findings that emerged in the intervening years since the
previous volume on hormonal control of growth in the section on the endocrine system of the …

Background: The prevalence of obesity in childhood has increased dramatically in recent
decades with increased risk of developing cardiometabolic and other comorbidities …

Obesity is associated with insulin resistance in metabolic tissues such as adipose, liver, and
muscle, but it is unclear whether nonclassical target tissues, such as those of the …

Growth hormone (GH) is critical for achieving normal structural growth. In addition, GH plays
an important role in regulating metabolic function. GH acts through its GH receptor (GHR) to …