Discovery of highly potent proapoptotic antiestrogens in a series of androst-5, 16-dienes D-modified with imidazole-annulated pendants
V Birukova, A Scherbakov, A Ilina, D Salnikova… - The Journal of Steroid …, 2023 - Elsevier
Heterocyclic derivatives of steroid hormones are potent anticancer agents, which are used in
the chemotherapy of breast and prostate cancers. Here, we describe a novel series of …
the chemotherapy of breast and prostate cancers. Here, we describe a novel series of …
Design and synthesis of phosphoryl-substituted steroidal pyridazines (Pho-STPYRs) as potent estrogen receptor alpha inhibitors: targeted treatment of hormone …
Estrogen receptor alpha (ERα) is an important target for the discovery of new therapeutic
drugs against hormone-dependent breast cancer. A series of phosphoryl-substituted …
drugs against hormone-dependent breast cancer. A series of phosphoryl-substituted …
Failure of Androgen-Deprivation Therapy Due to Ectopic hCG Secretion
T Gagliano-Jucá, MS Hirsch… - New England Journal …, 2023 - Mass Medical Soc
Failure of Androgen-Deprivation Therapy Due to Ectopic hCG Secretion | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Exploration and biological evaluation of 20‐vinyl pregnenes: A step forward toward selective modulators of the estrogen receptor α signaling for breast cancer …
V Malakhova, A Scherbakov, D Sorokin… - Archiv der …, 2024 - Wiley Online Library
A series of D‐ring modified steroids bearing a vinyl ketone pendant were synthesized and
evaluated for antiproliferative activity against breast cancer cell line and cytochromes P450 …
evaluated for antiproliferative activity against breast cancer cell line and cytochromes P450 …