CD4 T-cell subsets and the pathophysiology of inflammatory bowel disease

R Gomez-Bris, A Saez, B Herrero-Fernandez… - International journal of …, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated
idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or …

Pro-and anti-inflammatory roles of interleukin (IL)-33, IL-36, and IL-38 in inflammatory bowel disease

A Andoh, A Nishida - Journal of Gastroenterology, 2023 - Springer
Abstract Interleukin-33 (IL-33), IL-36, and IL-38 are members of the IL-1 cytokine family. The
expression of each cytokine has been reported to be increased in the inflamed mucosa of …

Identification and exploration of pharmacological pyroptosis-related biomarkers of ulcerative colitis

K Chen, S Shang, S Yu, L Cui, S Li, N He - Frontiers in Immunology, 2022 - frontiersin.org
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD). Its etiology is unclear.
Much evidence suggests that the death of abnormal intestinal epithelial cells (IECs) leads to …

Huangshan Floral Mushroom Polysaccharide Ameliorates Dextran Sulfate Sodium‐Induced Colitis in Mice by Modulating Th17/Treg Balance in a Gut Microbiota …

M Zou, Y Wang, Y Liu, S Xiong… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Ulcerative colitis (UC) is a common chronic recurrent inflammatory bowel disease.
This study attempts to reveal the improvement mechanism of floral mushroom …

Extracellular vesicles produced by bone marrow mesenchymal stem cells overexpressing programmed death‐ligand 1 ameliorate dextran sodium sulfate‐induced …

H He, Q Chen, H Fan, XY Leng, F Zhu… - Journal of …, 2022 - Wiley Online Library
Abstract Background and Aim Programmed death‐ligand 1 (PD‐L1) was involved in
regulating Th17/Treg cell balance in ulcerative colitis (UC). Extracellular vesicles (EVs) from …

Progress of Research into the Interleukin-1 Family in Cardiovascular Disease

Z Wu, C Luo, B Zheng - Journal of Inflammation Research, 2022 - Taylor & Francis
Inflammatory factors, such as the IL-1 family, are generally acknowledged to be involved in
systemic diseases and IL-1α and IL-1β, in particular, have been linked to cardiovascular …

Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles ameliorate ulcerative colitis through antioxidant effects

C Li, Y Zhou, M Yuan, Y Yang, R Song, G Xu… - Frontiers in …, 2023 - frontiersin.org
Introduction Astaxanthin (AST) is a type of carotenoid with strong antioxidant effects.
However, the development and use of AST are limited by its water insolubility and low …

New insights on IL‑36 in intestinal inflammation and colorectal cancer

M Li, W Jiang, Z Wang, Y Lu… - Experimental and …, 2023 - spandidos-publications.com
Abstract Interleukin (IL)‑36 is a member of the IL‑1 superfamily, which includes three
receptor agonists and one antagonist and exhibits a familial feature of inflammatory …

A comprehensive immunobiology review of IBD: With a specific glance to Th22 lymphocytes development, biology, function, and role in IBD

J Lv, YS Ibrahim, A Yumashev, A Hjazi, A Faraz… - International …, 2024 - Elsevier
The two primary forms of inflammatory disorders of the small intestine and colon that make
up inflammatory bowel disease (IBD) are ulcerative colitis (UC) and Crohn's disease (CD) …

Gut Microbiota Defines Functional Direction of Colonic Regulatory T Cells with Unique TCR Repertoires

S Byun, J Lee, YH Choi, H Ko, C Lee… - The Journal of …, 2024 - journals.aai.org
Intestinal microbiota and selected strains of commensal bacteria influence regulatory T
(Treg) cell functionality in the colon. Nevertheless, whether and how microbiota changes the …