Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

The application of next-generation sequencing to study congenital heart disease (CHD) is
increasingly providing new insights into the causes and mechanisms of this prevalent birth …

Congenital heart disease (CHD) is one of the most common birth defects. Studies in animal
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …

Congenital heart disease (CHD) is the most common congenital malformation and the
leading cause of mortality therein. Genetic etiologies contribute to an estimated 90% of CHD …

Aortic disease has many forms including aortic aneurysm and dissection, aortic coarctation
or abnormalities in aortic function, such as loss of aortic distensibility. Genetic analysis in …

Calcific aortic stenosis (AS) is the most common valve disease in the high-income countries
and is set to become a major health care burden with an aging population. 1 It is …

Atrial fibrillation (AF) is the most common type of arrhythmia. Epidemiological studies have
documented a substantial genetic component. More than 160 genes have been associated …

Bicuspid aortic valve (BAV) is the most common congenital heart defect, found in up to 2% of
the population and associated with a 30% lifetime risk of complications. BAV is inherited as …

Aims The aim of this study was to use human genetics to investigate the pathogenesis of
sick sinus syndrome (SSS) and the role of risk factors in its development. Methods and …