In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

Pseudomonas aeruginosa is a remarkably versatile environmental bacterium with an
extraordinary capacity to infect the cystic fibrosis (CF) lung. Infection with P. aeruginosa …

Background Chronic airway inflammation is the main driver of pathogenesis in respiratory
diseases such as severe asthma, chronic obstructive pulmonary disease, cystic fibrosis (CF) …

Pseudomonas aeruginosa is a leading cause of hospital-acquired pneumonia and chronic
lung infections in cystic fibrosis patients. Iron is essential for bacterial growth, and P …

Airway macrophages (AMs) play key roles in the maintenance of lung immune tolerance.
Tissue tailored, highly specialised and strategically positioned, AMs are critical sentinels of …

The appearance of multidrug resistant bacteria and growing antibiotic resistance is leading
to a continuous need for discovering new drugs and alternative treatments against …

Gut microbiota is the aggregate of all microorganisms in the human digestive system. There
are 1014 CFU/mL of such microorganisms in the human body, including bacteria, viruses …

Respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD),
are critical areas of medical research, as millions of people are affected worldwide. In fact …

Background Cystic fibrosis (CF) is a life-threatening genetic disorder, characterized by
chronic microbial lung infections due to abnormally viscous mucus secretions within …

Despite the implementation of cystic fibrosis (CF) newborn screening programs across the
United States, the identification of CFTR gene variants in nonwhite populations compared …