Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes
DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …
Single-molecule views of protein movement on single-stranded DNA
The advent of new technologies allowing the study of single biological molecules continues
to have a major impact on studies of interacting systems as well as enzyme reactions. These …
to have a major impact on studies of interacting systems as well as enzyme reactions. These …
Inhibition of homologous recombination in human cells by targeting RAD51 recombinase
F Huang, OM Mazina, IJ Zentner… - Journal of medicinal …, 2012 - ACS Publications
The homologous recombination (HR) pathway plays a crucial role in the repair of DNA
double-strand breaks (DSBs) and interstrand cross-links (ICLs). RAD51, a key protein of HR …
double-strand breaks (DSBs) and interstrand cross-links (ICLs). RAD51, a key protein of HR …
[HTML][HTML] Mechanisms and regulation of replication fork reversal
DNA replication is remarkably accurate with estimates of only a handful of mutations per
human genome per cell division cycle. Replication stress caused by DNA lesions …
human genome per cell division cycle. Replication stress caused by DNA lesions …
Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance
S Ohba, J Mukherjee, WL See, RO Pieper - Cancer research, 2014 - AACR
Abstract Isocitrate dehydrogenase 1 (IDH1) mutations occur in most lower grade glioma and
not only drive gliomagenesis but are also associated with longer patient survival and …
not only drive gliomagenesis but are also associated with longer patient survival and …
HOP2-MND1 modulates RAD51 binding to nucleotides and DNA
DV Bugreev, F Huang, OM Mazina, RJ Pezza… - Nature …, 2014 - nature.com
The HOP2-MND1 heterodimer is required for progression of homologous recombination in
eukaryotes. In vitro, HOP2-MND1 stimulates the DNA strand exchange activities of RAD51 …
eukaryotes. In vitro, HOP2-MND1 stimulates the DNA strand exchange activities of RAD51 …
Replication forks stalled at ultraviolet lesions are rescued via RecA and RuvABC protein-catalyzed disintegration in Escherichia coli
SR Khan, A Kuzminov - Journal of Biological Chemistry, 2012 - ASBMB
Ultraviolet (UV) irradiation is not known to induce chromosomal fragmentation in sublethal
doses, and yet UV irradiation causes genetic instability and cancer, suggesting that …
doses, and yet UV irradiation causes genetic instability and cancer, suggesting that …
So similar yet so different: The two ends of a double strand break
KP Kim, EV Mirkin - … Research/Fundamental and Molecular Mechanisms of …, 2018 - Elsevier
Homologous recombination (HR) is essential for ensuring proper segregation of
chromosomes in the first round of meiotic division. HR is also crucial for preserving genomic …
chromosomes in the first round of meiotic division. HR is also crucial for preserving genomic …
Polarity and bypass of DNA heterology during branch migration of Holliday junctions by human RAD54, BLM, and RECQ1 proteins
Several proteins have been shown to catalyze branch migration (BM) of the Holliday
junction, a key intermediate in DNA repair and recombination. Here, using joint molecules …
junction, a key intermediate in DNA repair and recombination. Here, using joint molecules …
Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?
RYL Tsai - Cellular and Molecular Life Sciences, 2016 - Springer
Stem cells are endowed with the awesome power of self-renewal and multi-lineage
differentiation that allows them to be major contributors to tissue homeostasis. Owing to their …
differentiation that allows them to be major contributors to tissue homeostasis. Owing to their …