Ligand-based design on the dog-bone-shaped BIBR1532 pharmacophoric features and synthesis of novel analogues as promising telomerase inhibitors with in vitro …
Telomerase is an outstanding biological target for cancer treatment. BIBR1532 is a non-
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
New Benzimidazole-, 1,2,4-Triazole-, and 1,3,5-Triazine-Based Derivatives as Potential EGFRWT and EGFRT790M Inhibitors: Microwave-Assisted Synthesis …
A new series of benzimidazole, 1, 2, 4-triazole, and 1, 3, 5-triazine derivatives were
designed and synthesized using a microwave irradiation synthetic approach utilizing 2 …
designed and synthesized using a microwave irradiation synthetic approach utilizing 2 …
Design, synthesis, in vitro anticancer and antimicrobial evaluation, SAR analysis, molecular docking and dynamic simulation of new pyrazoles, triazoles and …
HA Radwan, I Ahmad, IMM Othman… - Journal of Molecular …, 2022 - Elsevier
A new series of pyrazoles, triazoles and pyridazines based isoxazole were synthesized, and
well characterized. Their antibacterial, antifungal and cytotoxic activities were successfully …
well characterized. Their antibacterial, antifungal and cytotoxic activities were successfully …
Emerging insights into pyrazoline motifs: A comprehensive exploration of biological mechanisms and prospects for future advancements
The prevalence of cancer and neurodegenerative diseases, such as Alzheimer's and
Parkinson's, continues to rise worldwide, presenting a significant health burden. Despite …
Parkinson's, continues to rise worldwide, presenting a significant health burden. Despite …
Discovery of novel pyridazine-tethered sulfonamides as carbonic anhydrase II inhibitors for the management of glaucoma
As a progressive neuropathic condition, glaucoma can cause lifelong blindness if left
untreated. Novel phenylpyridazine-tethered sulfonamides were designed as selective …
untreated. Novel phenylpyridazine-tethered sulfonamides were designed as selective …
Docking studies of some novel Hetrocyclic compound as Acat inhibitors: A meta analysis
We use molecular modelling and pharmacological testing to identify TCM compounds that
may suppress SQS activity. By utilising previously established SQS inhibitors, ten HipHop …
may suppress SQS activity. By utilising previously established SQS inhibitors, ten HipHop …
[HTML][HTML] Design, synthesis and biological activity of chalcone derivatives containing pyridazine
S Chen, M Zhang, S Feng, C Gong, Y Zhou… - Arabian Journal of …, 2023 - Elsevier
Inspired by the application of fungicide from natural products, a series of chalcone
derivatives containing pyridazine were designed, synthesized, and evaluated for their …
derivatives containing pyridazine were designed, synthesized, and evaluated for their …
Recent contributions of pyridazine as a privileged scaffold of anticancer agents in medicinal chemistry: An updated review
ZQ Liu, Q Zhang, YL Liu, XQ Yu, RH Chui… - Bioorganic & Medicinal …, 2024 - Elsevier
Pyridazine, as a privileged scaffold, has been extensively utilized in drug development due
to its multiple biological activities. Especially around its distinctive anticancer property, a …
to its multiple biological activities. Especially around its distinctive anticancer property, a …
Nanoparticles of a pyrazolo-pyridazine derivative as potential EGFR and CDK-2 inhibitors: design, structure determination, anticancer evaluation and in silico studies
The strategic planning of this study is based upon using the nanoformulation method to
prepare nanoparticles 4-SLNs and 4-LPHNPs of the previously prepared 4, 5-diphenyl-1 H …
prepare nanoparticles 4-SLNs and 4-LPHNPs of the previously prepared 4, 5-diphenyl-1 H …
Discovery of pyridine-sulfonamide hybrids as a new scaffold for the development of potential VEGFR-2 inhibitors and apoptosis inducers
MF Ahmed, EY Santali - Bioorganic Chemistry, 2021 - Elsevier
New sulfonamide derivatives have been synthesized and tested as antitumor agents. All
newly synthesized compounds were tested in vitro against 60 lines of human cancer cells …
newly synthesized compounds were tested in vitro against 60 lines of human cancer cells …