Optimal implantation site for pancreatic islet transplantation
Background Since the first report of successful pancreatic islet transplantation to reverse
hyperglycaemia in diabetic rodents, there has been great interest in determining the optimal …
hyperglycaemia in diabetic rodents, there has been great interest in determining the optimal …
Revascularization of transplanted pancreatic islets and role of the transplantation site
Since the initial reporting of the successful reversal of hyperglycemia through the
transplantation of pancreatic islets, significant research efforts have been conducted in …
transplantation of pancreatic islets, significant research efforts have been conducted in …
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
X Li, N Padhan, EO Sjöström, FP Roche… - Nature …, 2016 - nature.com
The specific role of VEGFA-induced permeability and vascular leakage in physiology and
pathology has remained unclear. Here we show that VEGFA-induced vascular leakage …
pathology has remained unclear. Here we show that VEGFA-induced vascular leakage …
Anti-inflammatory peptide-functionalized hydrogels for insulin-secreting cell encapsulation
Pancreatic islet encapsulation within semi-permeable materials has been proposed for
transplantation therapy of type I diabetes mellitus. Polymer hydrogel networks used for this …
transplantation therapy of type I diabetes mellitus. Polymer hydrogel networks used for this …
Clinical and experimental pancreatic islet transplantation to striated muscle: establishment of a vascular system similar to that in native islets
G Christoffersson, J Henriksnäs, L Johansson… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Curing type 1 diabetes by transplanting pancreatic islets into the liver is
associated with poor long-term outcome and graft failure at least partly due to inadequate …
associated with poor long-term outcome and graft failure at least partly due to inadequate …
Alternative transplantation sites for pancreatic islet grafts
E Cantarelli, L Piemonti - Current diabetes reports, 2011 - Springer
The liver is the current site of choice for pancreatic islet transplantation, even though it is far
from being an ideal site because of immunologic, anatomic, and physiologic factors leading …
from being an ideal site because of immunologic, anatomic, and physiologic factors leading …
Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes
Summary The transcription factor Neurogenin3 (Ngn3) is required for islet-cell type
specification. Here, we show that hepatic gene transfer of Ngn3 transiently induces insulin in …
specification. Here, we show that hepatic gene transfer of Ngn3 transiently induces insulin in …
Islet transplantation: alternative sites
A Rajab - Current diabetes reports, 2010 - Springer
The portal vein is currently the site of choice for clinical islet transplantation, even though it is
far from being an ideal site. Low oxygen tension and the induction of an inflammatory …
far from being an ideal site. Low oxygen tension and the induction of an inflammatory …
Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes
Islet transplantation holds significant promise as a curative approach for type 1 diabetes
(T1D). However, the transition of islet transplantation from the experimental phase to …
(T1D). However, the transition of islet transplantation from the experimental phase to …
Islet transplantation a decade later and strategies for filling a half-full glass
RP Robertson - Diabetes, 2010 - Am Diabetes Assoc
Alloislet transplantation for the treatment of type 1 diabetes enjoyed highly favorable status
in the first half of the last decade but declined in favor during the second half. In this …
in the first half of the last decade but declined in favor during the second half. In this …