Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …

Immune checkpoint blockade (ICB) has revolutionized modern cancer therapy, arousing
great interest in the neuro-oncology community. While several reports show that subsets of …

Over the past decade, the emergence of effective immunotherapies has revolutionized the
clinical management of many types of cancers. However, long-term durable tumour control …

Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

BACKGROUND Recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma
(HNSCC) is generally an incurable disease, with patients experiencing median survival of …

Importance The KEYNOTE-177 trial demonstrated that patients with metastatic colorectal
cancer (MCRC) with high microsatellite instability (MSI-H) and/or mismatch repair deficiency …

The role of tumor mutational burden (TMB) in shaping tumor immunity is a key question that
has not been addressable using genetically engineered mouse models (GEMMs) of lung …

Neuroendocrine neoplasms (NENs) are a rare group of cancers with heterogeneous
behaviour and mostly of unknown aetiology. Excluding some infrequent hereditary cancer …

Simple Summary Polymerase delta 1 (POLD1), a catalytic and proofreading subunit of the
human DNA polymerase delta (Polδ), plays a vital role in maintaining the stability of the …

Simple Summary The landscape of gastric cancer treatment has changed owing to the
widespread use of immune checkpoint inhibitors. Only a subset of patients, though, have …