NF‐κB signaling in inflammation and cancer

T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

Antioxidant, anti-inflammatory, anti-menopausal, and anti-cancer effects of lignans and their metabolites

WY Jang, MY Kim, JY Cho - International journal of molecular sciences, 2022 - mdpi.com
Since chronic inflammation can be seen in severe, long-lasting diseases such as cancer,
there is a high demand for effective methods to modulate inflammatory responses. Among …

Reactive oxygen species and NRF2 signaling, friends or foes in cancer?

R Wang, L Liang, M Matsumoto, K Iwata, A Umemura… - Biomolecules, 2023 - mdpi.com
The imbalance between reactive oxygen species (ROS) production and clearance causes
oxidative stress and ROS, which play a central role in regulating cell and tissue physiology …

The role of natural products and their multitargeted approach to treat solid cancer

N Muhammad, D Usmani, M Tarique, H Naz, M Ashraf… - Cells, 2022 - mdpi.com
Natural products play a critical role in the discovery and development of numerous drugs for
the treatment of various types of cancer. These phytochemicals have demonstrated anti …

The crosstalk between Nrf2 and NF-κB pathways in coronary artery disease: Can it be regulated by SIRT6?

E Casper - Life sciences, 2023 - Elsevier
Coronary artery disease (CAD) is the leading cause of death worldwide. Oxidative stress
and inflammation are major mechanisms responsible for the progression of CAD. Nuclear …

Targeting PI3K/Akt/mTOR pathway by different flavonoids: a cancer chemopreventive approach

TA Zughaibi, M Suhail, M Tarique, S Tabrez - International Journal of …, 2021 - mdpi.com
Cancer is, globally, one of the main causes of death. Even though various therapies are
available, they are still painful because of their adverse side effects. Available treatments …

Anti-inflammatory mechanisms of dietary flavones: tapping into nature to control chronic inflammation in obesity and cancer

A Kariagina, AI Doseff - International Journal of Molecular Sciences, 2022 - mdpi.com
Flavones are natural phytochemicals broadly distributed in our diet. Their anti-inflammatory
properties provide unique opportunities to control the innate immune system and …

Polyphenols as anticancer agents: Toxicological concern to healthy cells

B Islam, M Suhail, MK Khan, TA Zughaibi… - Phytotherapy …, 2021 - Wiley Online Library
Polyphenols are a group of diverse chemical compounds present in a wide range of plants.
Various biological properties such as antiallergic, antiviral, antibacterial, anticarcinogenic …

Targeting a transcription factor NF-κB by green tea catechins using in silico and in vitro studies in pancreatic cancer

M Suhail, M Rehan, M Tarique, S Tabrez… - Frontiers in …, 2023 - frontiersin.org
Pancreatic cancer remains a lethal disease and a major public health problem globally.
Nuclear factor-kappa B (NF-κB) has been identified as a therapeutic target in several …

Anticancer perspective of 6-shogaol: Anticancer properties, mechanism of action, synergism and delivery system

Y Jia, X Li, X Meng, J Lei, Y Xia, L Yu - Chinese Medicine, 2023 - Springer
Cancer is a malignant disease that has plagued human beings all the time, but the treatment
effect of commonly used anticancer drugs in clinical practice is not ideal by reason of their …