Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators
Neurotransmitters and neuromodulators have a wide range of key roles throughout the
nervous system. However, their dynamics in both health and disease have been challenging …
nervous system. However, their dynamics in both health and disease have been challenging …
[HTML][HTML] Cellular circuits in the brain and their modulation in acute and chronic pain
Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …
Decoding molecular and cellular heterogeneity of mouse nucleus accumbens
The nucleus accumbens (NAc) plays an important role in regulating multiple behaviors, and
its dysfunction has been linked to many neural disorders. However, the molecular, cellular …
its dysfunction has been linked to many neural disorders. However, the molecular, cellular …
[PDF][PDF] Responses and functions of dopamine in nucleus accumbens core during social behaviors
Social behaviors are among the most important motivated behaviors. How dopamine (DA),
a" reward" signal, releases during social behaviors has been a topic of interest for decades …
a" reward" signal, releases during social behaviors has been a topic of interest for decades …
[PDF][PDF] Dopamine release in the nucleus accumbens core signals perceived saliency
A large body of work has aimed to define the precise information encoded by dopaminergic
projections innervating the nucleus accumbens (NAc). Prevailing models are based on …
projections innervating the nucleus accumbens (NAc). Prevailing models are based on …
Dopamine and addiction
RA Wise, MA Robble - Annual review of psychology, 2020 - annualreviews.org
Addiction is commonly identified with habitual nonmedical self-administration of drugs. It is
usually defined by characteristics of intoxication or by characteristics of withdrawal …
usually defined by characteristics of intoxication or by characteristics of withdrawal …
An expanded palette of dopamine sensors for multiplex imaging in vivo
Genetically encoded dopamine sensors based on green fluorescent protein (GFP) enable
high-resolution imaging of dopamine dynamics in behaving animals. However, these GFP …
high-resolution imaging of dopamine dynamics in behaving animals. However, these GFP …
[PDF][PDF] Imaging neurotransmitter and neuromodulator dynamics in vivo with genetically encoded indicators
BL Sabatini, L Tian - Neuron, 2020 - cell.com
The actions of neuromodulation are thought to mediate the ability of the mammalian brain to
dynamically adjust its functional state in response to changes in the environment. Altered …
dynamically adjust its functional state in response to changes in the environment. Altered …
Unique functional responses differentially map onto genetic subtypes of dopamine neurons
Dopamine neurons are characterized by their response to unexpected rewards, but they
also fire during movement and aversive stimuli. Dopamine neuron diversity has been …
also fire during movement and aversive stimuli. Dopamine neuron diversity has been …
NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model
Emotional stress is considered a severe pathogenetic factor of psychiatric disorders.
However, the circuit mechanisms remain largely unclear. Using a three-chamber vicarious …
However, the circuit mechanisms remain largely unclear. Using a three-chamber vicarious …