Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions

A Shafqat, MC Masters, U Tripathi, T Tchkonia… - Ageing Research …, 2024 - Elsevier
It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …

[HTML][HTML] Post-COVID-Syndrom mit Fatigue und Belastungsintoleranz: Myalgische Enzephalomyelitis bzw. Chronisches Fatigue-Syndrom

H Renz-Polster, C Scheibenbogen - Die Innere Medizin, 2022 - Springer
Hintergrund Ein erheblicher Teil der Verläufe des Post-COVID-Syndroms (COVID
„coronavirus disease “) erfüllt die Diagnosekriterien für Myalgische Enzephalomyelitis …

[HTML][HTML] Tissue specific signature of HHV-6 infection in ME/CFS

F Kasimir, D Toomey, Z Liu, AC Kaiping… - Frontiers in Molecular …, 2022 - frontiersin.org
First exposure to various human herpesviruses (HHVs) including HHV-6, HCMV and EBV
does not cause a life-threatening disease. In fact, most individuals are frequently unaware of …

Conditional RNA interference in mammalian cells via RNA transactivation

Y Zhou, P Sheng, J Li, Y Li, M Xie, AA Green - Nature Communications, 2024 - nature.com
RNA interference (RNAi) is a powerful tool for sequence-specific gene knockdown in
therapeutic and research applications. However, spatiotemporal control of RNAi is required …

Controllable three-dimensional DNA nanomachine-mediated electrochemical biosensing platform for rapid and ultrasensitive detection of MicroRNA

D Li, XL Zhang, YQ Chai, R Yuan - Analytical Chemistry, 2023 - ACS Publications
In this work, a high-efficiency controllable three-dimensional (3D) DNA nanomachine
(CDNM) was reasonably developed by regulating the diameter of the core and the length of …

Ultrasensitive electrochemical biosensor with powerful triple cascade signal amplification for detection of microRNA

X Wang, WW Liu, LL Long, SY Tan, YQ Chai… - Analytical …, 2024 - ACS Publications
In this work, by ingeniously integrating catalytic hairpin assembly (CHA), double-end Mg2+-
dependent DNAzyme, and hybridization chain reaction (HCR) as a triple cascade signal …

Multifunctional DNA Tetrahedron for Alzheimer's Disease Mitochondria-Targeted Therapy by MicroRNA Regulation

W Li, X Peng, X Mei, M Dong, Y Li… - ACS Applied Materials & …, 2023 - ACS Publications
The principal hallmark of Alzheimer's disease (AD) is neuron mitochondrial dysfunction,
whereas mitochondrial miRNAs potentially play important roles. Nevertheless, efficacious …

The Acid-Stimulated Self-Assembled DNA Nanonetwork for Sensitive Detection and Living Cancer Cell Imaging of MicroRNA-221

Y Han, M Jiang, J Zhou, H Lei, R Yuan… - Analytical …, 2024 - ACS Publications
Herein, a novel functional DNA structure, acid-stimulated self-assembly DNA nanonetwork
(ASDN), was proposed for miRNA-221 sensitive detection and high-resolution living cancer …

Orderly Aggregated Catalytic Hairpin Assembly for Synchronous Ultrasensitive Detecting and High-Efficiency Co-Localization Imaging of Dual-miRNAs in Living Cells

J Zhou, F Liu, Y Han, H Li, S Wei, Y Ouyang… - Analytical …, 2023 - ACS Publications
In this work, the orderly aggregated catalytic hairpin assembly (OA-CHA) was developed for
synchronous ultrasensitive detection and high-efficiency colocalization imaging of dual …

[HTML][HTML] HSV-1 and cellular miRNAs in CSF-derived exosomes as diagnostically relevant biomarkers for neuroinflammation

C Scheiber, HC Klein, JM Schneider, T Schulz… - Cells, 2024 - mdpi.com
Virus-associated chronic inflammation may contribute to autoimmunity in a number of
diseases. In the brain, autoimmune encephalitis appears related to fluctuating reactivation …