Tumour–host interactions through the lens of Drosophila
There is a large gap between the deep understanding of mechanisms driving tumour growth
and the reasons why patients ultimately die of cancer. It is now appreciated that interactions …
and the reasons why patients ultimately die of cancer. It is now appreciated that interactions …
Using Drosophila to uncover the role of organismal physiology and the tumor microenvironment in cancer
C Khan, NM Rusan - Trends in Cancer, 2024 - cell.com
Cancer metastasis causes over 90% of cancer patient fatalities. Poor prognosis is
determined by tumor type, the tumor microenvironment (TME), organ-specific biology, and …
determined by tumor type, the tumor microenvironment (TME), organ-specific biology, and …
Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies
Abstract The Transgenic RNAi Project (TRiP), a Drosophila melanogaster functional
genomics platform at Harvard Medical School, was initiated in 2008 to generate and …
genomics platform at Harvard Medical School, was initiated in 2008 to generate and …
ZnT7 RNAi favors RafGOFscrib−/−-induced tumor growth and invasion in Drosophila through JNK signaling pathway
T Wei, X Ji, Y Gao, X Zhu, G Xiao - Oncogene, 2021 - nature.com
The disruption of zinc homeostasis has been identified in patients suffering from various
cancers, but a causative relationship has not yet been established. Drosophila …
cancers, but a causative relationship has not yet been established. Drosophila …
Chicken skin-derived collagen peptides chelated zinc promotes zinc absorption and represses tumor growth and invasion in vivo by suppressing autophagy
T Liu, L Zou, X Ji, G Xiao - Frontiers in nutrition, 2022 - frontiersin.org
To improve the utilization value of chicken by-products, we utilized the method of step-by-
step hydrolysis with bromelain and flavourzyme to prepare low molecular weight chicken …
step hydrolysis with bromelain and flavourzyme to prepare low molecular weight chicken …
The ECSIT mediated Toll3-dorsal-ALFs pathway inhibits bacterial amplification in Kuruma shrimp
D Ding, X Sun, M Yan, Q Chen, L Gao… - Frontiers in …, 2022 - frontiersin.org
The Toll signaling pathway plays an important role in animal innate immunity. However, its
activation and signal transmission greatly differ across species and need to be investigated …
activation and signal transmission greatly differ across species and need to be investigated …
RasV12; scrib−/− Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions
The phenomenon of how oncogenes and tumor-suppressor mutations can synergize to
promote tumor fitness and cancer progression can be studied in relatively simple animal …
promote tumor fitness and cancer progression can be studied in relatively simple animal …
Drosophila innate immunity suppresses the survival of xenografted mammalian tumor cells
A Aida, K Yuswan, Y Kawai, K Hasegawa… - Scientific Reports, 2023 - nature.com
Patient-derived xenograft (PDX) is an emerging tool established in immunodeficient
vertebrate models to assess individualized treatments for cancer patients. Current xenograft …
vertebrate models to assess individualized treatments for cancer patients. Current xenograft …
E2 enzyme Bruce negatively regulates Hippo signaling through POSH-mediated expanded degradation
S Song, X Ma - Cell Death & Disease, 2023 - nature.com
The Hippo pathway is a master regulator of organ growth, stem cell renewal, and
tumorigenesis, its activation is tightly controlled by various post-translational modifications …
tumorigenesis, its activation is tightly controlled by various post-translational modifications …
Modelling Cancer Metastasis in Drosophila melanogaster
Cancer metastasis, the process by which tumour cells spread throughout the body and form
secondary tumours at distant sites, is the leading cause of cancer-related deaths. The …
secondary tumours at distant sites, is the leading cause of cancer-related deaths. The …