Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

The emerging nature of astrocyte diversity

BS Khakh, B Deneen - Annual review of neuroscience, 2019 - annualreviews.org
Astrocytes are morphologically complex, ubiquitous cells that are viewed as a
homogeneous population tiling the entire central nervous system (CNS). However, this view …

Making sense of astrocytic calcium signals—from acquisition to interpretation

A Semyanov, C Henneberger, A Agarwal - Nature Reviews …, 2020 - nature.com
Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …

Astrocyte heterogeneity: impact to brain aging and disease

I Matias, J Morgado, FCA Gomes - Frontiers in aging neuroscience, 2019 - frontiersin.org
Astrocytes, one of the largest glial cell population in the central nervous system (CNS), play
a key function in several events of brain development and function, such as synapse …

Astrocyte calcium signaling: the third wave

N Bazargani, D Attwell - Nature neuroscience, 2016 - nature.com
The discovery that transient elevations of calcium concentration occur in astrocytes, and
release'gliotransmitters' which act on neurons and vascular smooth muscle, led to the idea …

Diversity of astrocyte functions and phenotypes in neural circuits

BS Khakh, MV Sofroniew - Nature neuroscience, 2015 - nature.com
Astrocytes tile the entire CNS. They are vital for neural circuit function, but have traditionally
been viewed as simple, homogenous cells that serve the same essential supportive roles …

Chemical landscape for tissue clearing based on hydrophilic reagents

K Tainaka, TC Murakami, EA Susaki, C Shimizu… - Cell reports, 2018 - cell.com
We describe a strategy for developing hydrophilic chemical cocktails for tissue delipidation,
decoloring, refractive index (RI) matching, and decalcification, based on comprehensive …

Transient opening of the mitochondrial permeability transition pore induces microdomain calcium transients in astrocyte processes

A Agarwal, PH Wu, EG Hughes, M Fukaya… - Neuron, 2017 - cell.com
Astrocytes extend highly branched processes that form functionally isolated microdomains,
facilitating local homeostasis by redistributing ions, removing neurotransmitters, and …

Gliotransmission: beyond black-and-white

I Savtchouk, A Volterra - Journal of Neuroscience, 2018 - Soc Neuroscience
Astrocytes are highly complex cells with many emerging putative roles in brain function. Of
these, gliotransmission (active information transfer from glia to neurons) has probably the …

The role of astrocyte‐mediated plasticity in neural circuit development and function

NA Perez-Catalan, CQ Doe, SD Ackerman - Neural development, 2021 - Springer
Neuronal networks are capable of undergoing rapid structural and functional changes called
plasticity, which are essential for shaping circuit function during nervous system …