In this comprehensive review, we examine the main preclinical and clinical investigations
assessing the effects of different forms of choline supplementation currently available …

Cognitive decline is a common symptom at advanced stage of type 1 diabetes (T1D), but its
potential pathogenesis remains unclear. In this study, therefore, we investigated changes in …

Background Moderate egg intake has been associated with better cognitive performance in
observational studies. This association may be due to the rich content of choline, especially …

There is an urgent need to identify modifiable environmental risk factors that reduce the
incidence of Alzheimer's disease (AD). The B‐like vitamin choline plays key roles in body …

Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease, and
metabolomics plays a hub role in predictive, preventive, and personalized medicine (PPPM) …

Glutamate (Glu), the key excitatory neurotransmitter in the central nervous system, is
considered essential for brain functioning and has a vital role in learning and memory …

Zebrafish (Danio rerio) are a recognized model for studying the pathogenesis of cognitive
deficits and the mechanisms underlying behavioral impairments, including the …

Unpredictable chronic mild stress (UCMS) model is the most established method to study
neurobiological mechanisms of depression. This work was intended to explore the efficacy …

Anesthesia and surgery (A+ S) are risk factors for patients to develop postoperative delirium
(POD). However, the pathogenesis of POD remains largely to be determined. We employed …

Semen Strychni has long been used for the treatment of rheumatoid arthritis, facioplegia and
myasthenia gravis due to its anti-inflammation and anti-nociceptive properties in China …