Several pathogens associated with chronic infections, including Pseudomonas aeruginosa
in cystic fibrosis pneumonia, Haemophilus influenzae and Streptococcus pneumoniae in …

New molecular, cellular, and immunologic techniques used to study host–pathogen
interactions have led to a reexamination of the role of infection in chronic obstructive …

Lung cancer development is associated with extensive pulmonary inflammation. In addition,
the linkage between chronic obstructive pulmonary disease (COPD) and lung cancer has …

Rationale: Severe exacerbations of chronic obstructive pulmonary disease (COPD) are
major causes of health care costs mostly related to hospitalization. The role of infections in …

ABSTRACT COPD is a major global concern, increasingly so in the context of ageing
populations. The role of infections in disease pathogenesis and progression is known to be …

Exacerbations of COPD are thought to be caused by complex interactions between the host,
bacteria, viruses, and environmental pollution. These factors increase the inflammatory …

Bacterial virulence relies on a delicate balance of signals interchanged between the
invading microbe and the host. This communication has been extensively perceived as a …

The normal lung has several defence mechanisms to deal with microorganisms. Lower
respiratory infections in the absence of lung disease are therefore relatively infrequent as …

Bronchiectasis is defined by permanent and abnormal widening of the bronchi. This process
occurs in the context of chronic airway infection and inflammation. It is usually diagnosed …

Background The culture of bronchial secretions from the lower airway has been reported to
be positive for potentially pathogenic microorganisms (PPMs) in patients with stable chronic …