Liquid‐assisted grinding mechanochemistry in the synthesis of pharmaceuticals

P Ying, J Yu, W Su - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Mechanochemical reactions by milling, grinding or other types of mechanical action have
emerged as a salient green approach because of its wide applications towards academic …

Updates on aldose reductase inhibitors for management of diabetic complications and non-diabetic diseases

A Singh Grewal, S Bhardwaj, D Pandita… - Mini reviews in …, 2016 - ingentaconnect.com
Diabetes mellitus occurrence has been associated to the modification of the physiological
levels of glucose and is often accompanied by several long-term complications, namely …

Mechanochemical preparation of hydantoins from amino esters: application to the synthesis of the antiepileptic drug phenytoin

L Konnert, B Reneaud, RM de Figueiredo… - The Journal of …, 2014 - ACS Publications
The eco-friendly preparation of 5-and 5, 5-disubstituted hydantoins from various amino ester
hydrochlorides and potassium cyanate in a planetary ball-mill is described. The one-pot/two …

Synthesis, spectroscopic characterization, X-ray crystal structure, antimicrobial, DNA-binding, alkaline phosphatase and insulin-mimetic studies of oxidovanadium (IV) …

KS Munawar, S Ali, MN Tahir, N Khalid… - Journal of …, 2020 - Taylor & Francis
A series of novel azomethine precursors were synthesized by the condensation reactions of
3-(trifluoromethyl) benzenamine (tfmb) with 2-hydroxybenzaldehyde (HL1)(tfmbs), 2, 3 …

Novel hydroxychalcone-based dual inhibitors of aldose reductase and α-glucosidase as potential therapeutic agents against diabetes mellitus and its complications

X Zhang, L Xu, H Chen, X Zhang, Y Lei… - Journal of Medicinal …, 2022 - ACS Publications
We designed a novel series of bifunctional inhibitors of α-glucosidase and aldose reductase
(ALR2) based on the structure of hydroxychalcone. The two enzymes relate to blood glucose …

Continuous synthesis of hydantoins: Intensifying the Bucherer–Bergs reaction

JL Monteiro, B Pieber, AG Corrêa, CO Kappe - Synlett, 2016 - thieme-connect.com
A continuous Bucherer–Bergs hydantoin synthesis utilizing intensified conditions is
reported. The methodology is characterized by a two-feed flow approach to independently …

Identification of novel pyrazole–rhodanine hybrid scaffolds as potent inhibitors of aldose reductase: design, synthesis, biological evaluation and molecular docking …

H Andleeb, Y Tehseen, SJA Shah, I Khan, J Iqbal… - RSC …, 2016 - pubs.rsc.org
In an effort to develop a new class of potent aldose reductase inhibitors, a series of 1, 3-
diarylpyrazole assimilated 3-substituted 4-oxo-2-thioxo-1, 3-thiazolidines (9a–n) was …

Direct access to multifunctionalized norcamphor scaffolds by asymmetric organocatalytic Diels–Alder reactions

R Mose, ME Jensen, G Preegel… - Angewandte …, 2015 - Wiley Online Library
A general organocatalytic cross‐dienamine activation strategy to produce chiral
multifunctionalized norcamphor compounds having a large diversity in substitution pattern is …

Synthesis, characterization, hypoglycemic and aldose reductase inhibition activity of arylsulfonylspiro [fluorene-9, 5′-imidazolidine]-2′, 4′-diones

Z Iqbal, S Hameed, S Ali, Y Tehseen, M Shahid… - European journal of …, 2015 - Elsevier
Abstract A series of 3-arylsulfonylspiroimidazolidine-2, 4-diones (2a-g) and their
corresponding rearranged products, 1-arylsulfonylspiroimidazolidine-2, 4-diones (3a-g) …

Investigation of derivatized Schiff base ligands of 1, 2, 4-triazole amine and their oxovanadium (IV) complexes: synthesis, structure, DNA binding, alkaline …

KS Munawar, S Ali, MN Tahir, N Khalid… - Russian Journal of …, 2015 - Springer
A series of novel azomethine precursors were derivatized by the condensation of 4H-1, 2, 4-
triazole-4-amine with salicylaldehyde (HL 1)(saltrz), 2, 3-dihydroxybenzaldehyde (HL …