Diabetes has emerged as one the leading detrimental factors for human life expectancy
worldwide. The disease is mainly considered as outcome of dysregulation in glucose …

Mitochondria-associated endoplasmic reticulum membrane (MAM) may have a role in
tubular injury in diabetic nephropathy (DN), but the precise mechanism remains unclear …

Glucagon-like peptide-1 signalling impacts glucose homeostasis and appetite thereby
indirectly affecting substrate availability at the whole-body level. The incretin canonically …

cAMP, a key player in many physiological processes, was classically considered to originate
solely from the plasma membrane (PM). This view was recently challenged by observations …

The blood‐retinal barrier (BRB), homeostasis, neuronal integrity, and metabolic processes
are all directly influenced by Müller cells, the most important retinal glial cells. We isolated …

We aimed to explore the active ingredients and molecular mechanism of Tripterygium
wilfordii (TW) in the treatment of diabetic nephropathy (DN) through network pharmacology …

Src homology 3 domain binding kinase 1 protects against hepa... : Hepatology Src homology 3
domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the …

Hepatitis B virus (HBV) is a major risk factor for serious liver diseases. The liver plays a
unique role in controlling carbohydrate metabolism to maintain the glucose level within the …

The gut microbiota and their metabolites are closely linked to obesity-related diseases, such
as type 2 diabetes, but their causal relationship and underlying mechanisms remain largely …

The cyclic AMP response element binding protein (CREB) contains a basic leucine zipper
motif (bZIP) that forms a coiled coil structure upon dimerization and specific DNA binding …