Adipose triglyceride lipase (ATGL) has been discovered 14 years ago and revised our view
on intracellular triglyceride (TG) mobilization–a process termed lipolysis. ATGL initiates the …

Fatty acids (FAs) activate and fuel UCP1-mediated non-shivering thermogenesis (NST) in
brown adipose tissue (BAT). Release of FAs from intracellular fat stores by adipose …

Short (< 10 days) periods of muscle disuse, often necessary for recovery from illness or
injury, lead to various negative health consequences. The current study investigated …

The ability of mammals to store and draw on fat reserves has been a driving force
throughout evolution in an environment with intermittent nutrient availability. The discovery …

Chronic activation of β3-adrenergic receptors (β3-ARs) expands the catabolic activity of both
brown and white adipose tissue by engaging uncoupling protein 1 (UCP1)-dependent and …

Visceral adipose tissue plays a critical role in numerous diseases. Although imaging studies
often show adipose involvement in abdominal diseases, their outcomes may vary from being …

Trypanosoma brucei causes African trypanosomiasis, colonizing adipose tissue and
inducing weight loss. Here we investigated the molecular mechanisms responsible for …

Emerging evidence suggests that impaired regulation of adipocyte lipolysis contributes to
the proinflammatory immune cell infiltration of metabolic tissues in obesity, a process that is …

Sirtuin 1 (SIRT1), an NAD+-dependent protein deacetylase, regulates a host of target
proteins, including peroxisome proliferator–activated receptor (PPAR)-γ coactivator-1α (PGC …

To liberate fatty acids (FAs) from intracellular stores, lipolysis is regulated by the activity of
the lipases adipose triglyceride lipase (ATGL), hormone-sensitive lipase and …