The physical frailty syndrome as a transition from homeostatic symphony to cacophony
Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …
Frailty: implications for clinical practice and public health
Frailty is an emerging global health burden, with major implications for clinical practice and
public health. The prevalence of frailty is expected to rise alongside rapid growth in the …
public health. The prevalence of frailty is expected to rise alongside rapid growth in the …
Multisystem physiological perspective of human frailty and its modulation by physical activity
JA Taylor, PL Greenhaff, DB Bartlett… - Physiological …, 2023 - journals.physiology.org
“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …
midlife, but the implications of this variation are poorly understood. We tested associations …
Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes?
The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …
has many connections with other systems and is, in fact, often considered as part of the …
A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge
Methods to quantify biological aging are emerging as new measurement tools for
epidemiology and population science and have been proposed as surrogate measures for …
epidemiology and population science and have been proposed as surrogate measures for …
Eleven telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: do they measure the same thing?
The geroscience hypothesis posits that therapies to slow biological processes of aging can
prevent disease and extend healthy years of life. To test such “geroprotective” therapies in …
prevent disease and extend healthy years of life. To test such “geroprotective” therapies in …
Age-related change in mobility: perspectives from life course epidemiology and geroscience
Mobility is the most studied and most relevant physical ability affecting quality of life with
strong prognostic value for disability and survival. Natural selection has built the “engine” of …
strong prognostic value for disability and survival. Natural selection has built the “engine” of …
[HTML][HTML] Biomarkers of aging for the identification and evaluation of longevity interventions
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup
JN Justice, L Ferrucci, AB Newman, VR Aroda… - Geroscience, 2018 - Springer
Recent advances indicate that biological aging is a potentially modifiable driver of late-life
function and chronic disease and have led to the development of geroscience-guided …
function and chronic disease and have led to the development of geroscience-guided …