Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

Simple Summary Breast cancer (BC) is the most frequent malignancy diagnosed in 2020
worldwide. Despite significant advances in BC therapy, its pathogenesis is still not fully …

We have previously described novel histone acetyltransferase (HAT) inhibitors that block
neuroblastoma cell growth in vitro. Here we show that two selected pyridoisothiazolone HAT …

Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene
expression by remodeling chromatin structure. An imbalance of histone acetylation caused …

Ovarian cancer is a common gynecological cancer that is found worldwide. Class III histone
deacetylase (HDAC) inhibitors, a new class of anticancer agents, induce autophagy in …

Breast cancer (BC) is the leading cause of death in women all over the world. Currently,
combined chemotherapy with two or more agents is considered a promising anti-cancer tool …

Breast cancer (BC) is a heterogeneous disease with different intrinsic subtypes. The most
aggressive subtype of BC–triple-negative breast cancer (TNBC) is characterized by high …

Background Breast cancer (BC) is the most common malignancy and the leading cause of
cancer-related death in women worldwide. Sirtuin inhibitors (SIRTi), belonging to the histone …

Background Metastatic initiation has many phenotypic similarities to epithelial-to-
mesenchymal transition, including loss of cell–cell adhesion, increased invasiveness, and …

Background The child cancer, neuroblastoma (NB), is characterised by a low incidence of
mutations and strong oncogenic embryonal driver signals. Many new targeted epigenetic …