To effectively build on the recent successes of immune checkpoint blockade, adoptive T cell
therapy and cancer vaccines, it is critical to rationally design combination strategies that will …

The study of miRNAs started in 1993, when Lee et al. observed their involvement in the
downregulation of a crucial protein known as LIN-14 in the nematode Caenorhabditis …

The infection of mammalian cells by viruses and innate immune responses to infection are
spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation …

Viral infection is usually studied at the population level by averaging over millions of cells.
However, infection at the single-cell level is highly heterogeneous, with most infected cells …

The impact of mosquito-borne flavivirus infections worldwide is significant, and many critical
aspects of these viruses' biology, including virus-host interactions, host cell requirements for …

Influenza Virus (IV) pneumonia is associated with severe damage of the lung epithelium and
respiratory failure. Apart from efficient host defense, structural repair of the injured epithelium …

Given the unprecedented scale of the recent Ebola and Zika viral epidemics, it is crucial to
understand the biology of host factors with broad antiviral action in order to develop novel …

Tumor cells harbor tens to thousands of genetic and epigenetic alterations that disrupt
cellular pathways, providing them with growth and survival advantages. However, these …

The cell intrinsic antiviral response of multicellular organisms developed over millions of
years and critically relies on the ability to sense and eliminate viral nucleic acids. Here we …

It is well-established that aberrant WNT expression and signaling is associated with
developmental defects, malignant transformation and carcinogenesis. More recently, WNT …