Epidemiology of stroke in sickle cell disease
FJ Kirkham, IA Lagunju - Journal of Clinical Medicine, 2021 - mdpi.com
Sickle cell disease is the most common cause of stroke in childhood, both ischaemic and
haemorrhagic, and it also affects adults with the condition. Without any screening or …
haemorrhagic, and it also affects adults with the condition. Without any screening or …
Genetic variation and sickle cell disease severity: a systematic review and meta-analysis
Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …
Sickle cell trait and the potential risk of severe coronavirus disease 2019—A mini‐review
TA Kehinde, MA Osundiji - European Journal of Haematology, 2020 - Wiley Online Library
Abstract Coronavirus Disease 2019 (COVID‐19) pandemic is a rapidly evolving public
health problem. The severity of COVID‐19 cases reported hitherto has varied greatly from …
health problem. The severity of COVID‐19 cases reported hitherto has varied greatly from …
The BACH1 inhibitor ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease
In sickle cell disease (SCD), heme released during intravascular hemolysis promotes
oxidative stress, inflammation, and vaso-occlusion. Conversely, free heme can also activate …
oxidative stress, inflammation, and vaso-occlusion. Conversely, free heme can also activate …
Heme oxygenase-1 and hemopexin gene polymorphisms and the risk of anti-tuberculosis drug-induced hepatotoxicity in China
W Liu, L Lu, H Pan, X He, M Zhang, N Wang… - …, 2022 - Taylor & Francis
Objective: To assess whether the risk of anti-tuberculosis drug-induced hepatotoxicity
(ATDH) might be influenced by heme oxygenase-1 (HMOX1) and hemopexin (HPX) gene …
(ATDH) might be influenced by heme oxygenase-1 (HMOX1) and hemopexin (HPX) gene …
Protocol for “Genetic composition of sickle cell disease in the Arab population: A systematic review”
Abstract Background Sickle Cell Disease (SCD) is a global health issue in hematology with
a progressively increasing prevalence. There are recent advances in the management of …
a progressively increasing prevalence. There are recent advances in the management of …
[HTML][HTML] Polymorphisms in the heme oxygenase-1 and bone morphogenetic protein receptor type 1b genes and estimated glomerular filtration rate in Brazilian sickle …
O Chinedu, WV Tonassé, DM Albuquerque… - … , Transfusion and Cell …, 2021 - SciELO Brasil
Introduction Mutations affecting genes involved in oxidative and signaling pathways may be
associated with kidney disease in sickle cell anemia. We determined the allele and …
associated with kidney disease in sickle cell anemia. We determined the allele and …
Transforming growth factor-β1: relation between its single-nucleotide genetic variants and sickle cell nephropathy
Background Sickle cell nephropathy is a complication of sickle cell disease characterized by
functional abnormalities of the kidney and glomeruli. Our study aimed to investigate the …
functional abnormalities of the kidney and glomeruli. Our study aimed to investigate the …
CCR5-Δ32 gene variant frequency in the Turkish Cypriot population
Recent UNAIDS reports (December 2019) indicate that 37.9 million people have been
affected by HIV infection around the globe in 2018, of which 1.7 million are cited as new …
affected by HIV infection around the globe in 2018, of which 1.7 million are cited as new …
Significance of heme oxygenase-1(HMOX1) gene on fetal hemoglobin induction in sickle cell anemia patients
P Hariharan, V Chavan, A Nadkarni - Scientific Reports, 2020 - nature.com
Though the patients with sickle cell anemia (SCA) inherit same genetic mutation, they show
considerable phenotypic heterogeneity. It has been observed that patients with elevated …
considerable phenotypic heterogeneity. It has been observed that patients with elevated …