Is insulin-like growth factor-1 involved in Parkinson's disease development?

I Castilla-Cortázar, GA Aguirre, G Femat-Roldán… - Journal of translational …, 2020 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder that results in the death of
dopaminergic neurons within the substantia nigra pars compacta and the reduction in …

Somatotropic‐Testicular Axis: A crosstalk between GH/IGF‐I and gonadal hormones during development, transition, and adult age

M Tenuta, F Carlomagno, B Cangiano, G Kanakis… - …, 2021 - Wiley Online Library
Background The hypothalamic‐pituitary‐gonadal (HPG) and hypothalamic‐pituitary‐
somatotropic (HPS) axes are strongly interconnected. Interactions between these axes are …

Role of the GH-IGF1 axis on the hypothalamus–pituitary–testicular axis function: lessons from Laron syndrome

R Cannarella, A Crafa, S La Vignera… - Endocrine …, 2021 - ec.bioscientifica.com
Background Animal studies suggest that insulin-like growth factor 1 (IGF1) may influence the
function of the hypothalamus–pituitary–testicular axis, especially in childhood, but the …

Why do normal children have acromegalic levels of IGF-I during puberty?

A Juul, NE Skakkebæk - The Journal of Clinical Endocrinology & …, 2019 - academic.oup.com
Context The rapid pubertal height growth is unique to humans, but why do we have it?
Although the spurt contributes 13% to 15% to the final adult height, we hypothesized that the …

Homozygous 6-bp deletion of IGFALS in a prepubertal boy with short stature

H Doi, I Kageyama, Y Katoh-Fukui, A Hattori… - Human Genome …, 2024 - nature.com
Biallelic IGFALS variants lead to acid‒labile subunit (ALS) deficiency characterized by
growth hormone resistance with or without delayed puberty. Here, we report a prepubertal …

IGFALS Gene Polymorphisms in Simmental Breed Cattle

R Genç, Z Sönmez - … Journal of Agriculture-Food Science and …, 2023 - agrifoodscience.com
Defining new genetic markers to understand the population structure and genetic basis of
cattle breeds, increase production and improve yield quality is of great importance in the …

[HTML][HTML] Diagnosis of Laron syndrome using monoplex-polymerase chain reaction technology with a whole-genome amplification template: A case report

A Neumann, MÁ Alcántara-Ortigoza… - World Journal of …, 2019 - ncbi.nlm.nih.gov
BACKGROUND Laron syndrome (LS) is an autosomal recessive hereditary condition
affecting only 1/1000000 births. The cause is associated with mutations in the growth …

Importancia de la Subunidad Ácido Lábil (ALS) en el crecimiento. Valores de normalidad, relación con otros factores de crecimiento y su variación en pacientes con …

P González Ildefonso - 2023 - gredos.usal.es
[ES] Las hipótesis son:-La determinación y valoración de forma conjunta de la ALS, IGF1 e
IGFBP3 ayuda a un mejor estudio y diagnóstico de la talla baja en pediatría.-Existen datos …

Efecto del consumo crónico de alcohol durante la gestación en la generación de estrés oxidante en neonatos de un modelo múrido con deficiencia parcial de IGF-1.

C Zertuche Mery - repositorio.tec.mx
El consumo de alcohol durante el embarazo es un factor de riesgo para el crecimiento
intrauterino retardado. Su consumo crónico puede activar el metabolismo por el citocromo …