The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

The heart is the first organ to form during embryonic development. Given the complex nature
of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital …

Background The pervasive expression of circular RNA is a recently discovered feature of
gene expression in highly diverged eukaryotes, but the functions of most circular RNAs are …

Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which
invade the developing embryo and persist by means of local self-renewal. However, the …

Using four-dimensional whole-embryo light sheet imaging with improved and accessible
computational tools, we longitudinally reconstruct early murine cardiac development at …

Mammalian Na+/Ca2+ exchangers are members of three branches of a much larger family
of transport proteins [the CaCA (Ca2+/cation antiporter) superfamily] whose main role is to …

In this review we discuss the major morphogenetic and regulative events that control
myocardial progenitor cells from the time that they delaminate from the epiblast in the …

Renal tubulointerstitial fibrosis is the common end point of progressive renal disease.
MicroRNA (miR)-214 and miR-21 are upregulated in models of renal injury, but the function …

Macrophages are important for tissue development, homeostasis as well as immune
response upon injury or infection. For a long time they were only seen as one uniform group …

The excitation–contraction coupling cycle in cardiac muscle is initiated by an influx of Ca2+
through voltage-dependent Ca2+ channels. Ca2+ influx induces a release of Ca2+ from the …