Increased risk of COVID-19 in patients with diabetes mellitus—Current challenges in pathophysiology, treatment and prevention

T Gęca, K Wojtowicz, P Guzik, T Gora - International journal of …, 2022 - mdpi.com
Coronavirus disease—COVID-19 (coronavirus disease 2019) has become the cause of the
global pandemic in the last three years. Its etiological factor is SARS-CoV-2 (Severe Acute …

CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications

S Feng, S Park, YK Choi, W Im - Journal of chemical theory and …, 2023 - ACS Publications
Molecular dynamics simulations of membranes and membrane proteins serve as
computational microscopes, revealing coordinated events at the membrane interface. As G …

N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

F Tian, B Tong, L Sun, S Shi, B Zheng, Z Wang, X Dong… - elife, 2021 - elifesciences.org
SARS-CoV-2 has been spreading around the world for the past year. Recently, several
variants such as B. 1.1. 7 (alpha), B. 1.351 (beta), and P. 1 (gamma), which share a key …

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

J Zhang, T Xiao, Y Cai, CL Lavine, H Peng, H Zhu… - Science, 2021 - science.org
The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
outcompeted previously prevalent variants and become a dominant strain worldwide. We …

Neuropilin-1 mediates SARS-CoV-2 infection of astrocytes in brain organoids, inducing inflammation leading to dysfunction and death of neurons

W Kong, M Montano, MJ Corley, E Helmy, H Kobayashi… - MBio, 2022 - Am Soc Microbiol
ABSTRACT Coronavirus disease 2019 (COVID-19) is frequently associated with
neurological deficits, but how severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Clinical grade ACE2 as a universal agent to block SARS‐CoV‐2 variants

V Monteil, B Eaton, E Postnikova, M Murphy… - EMBO Molecular …, 2022 - embopress.org
The recent emergence of multiple SARS‐CoV‐2 variants has caused considerable concern
due to both reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It …

Binding interactions between receptor-binding domain of spike protein and human angiotensin converting enzyme-2 in omicron variant

B Jawad, P Adhikari, R Podgornik… - The journal of physical …, 2022 - ACS Publications
The emergence of new SARS-CoV-2 Omicron variant of concern (OV) has exacerbated the
COVID-19 pandemic because of a large number of mutations in the spike protein …

Binding of human ACE2 and RBD of omicron enhanced by unique interaction patterns among SARS‐CoV‐2 variants of concern

S Kim, Y Liu, M Ziarnik, S Seo, Y Cao… - Journal of …, 2023 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus causing COVID‐
19, has continued to mutate and spread worldwide despite global vaccination efforts. In …

SARS-CoV-2: receptor and co-receptor tropism probability

N Eslami, PS Aghbash, A Shamekh… - Current …, 2022 - Springer
The recent pandemic which arose from China, is caused by a pathogenic virus named
“severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2)”. Its rapid global …

Possible use of phytochemicals for recovery from COVID-19-induced anosmia and ageusia

S Koyama, K Kondo, R Ueha, H Kashiwadani… - International Journal of …, 2021 - mdpi.com
The year 2020 became the year of the outbreak of coronavirus, SARS-CoV-2, which
escalated into a worldwide pandemic and continued into 2021. One of the unique symptoms …