Quercetin, as a member of flavonoids, has emerged as a potential therapeutic agent in
cardiovascular diseases (CVDs) in recent decades. In this comprehensive literature review …

The family of mitogen-activated protein kinases (MAPKs) consists of fourteen members and
has been implicated in regulation of virtually all cellular processes. MAPKs are divided into …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …

The challenge of precision medicine is to model complex interactions among DNA variants,
sets of phenotypes, and complex environmental factors and confounders. We have …

The hypothalamus is an important regulator of autonomic and endocrine functions also
involved in aging regulation. The aging process in the hypothalamus is accompanied by …

Objectives Insulin's ability to counterbalance catecholamine-induced lipolysis defines insulin
action in adipose tissue. Insulin suppresses lipolysis directly at the level of the adipocyte and …

The BXD recombinant inbred (RI) mouse strains are the largest and most deeply
phenotyped inbred panel of vertebrate organisms. RIs allow phenotyping of isogenic …

Studies in a broad range of animal species have revealed phenotypes that are caused by
ancestral life experiences, including stress and diet. Ancestral dietary macronutrient …

Recombinant inbred rodents form immortal genome-types that can be resampled deeply at
many stages, in both sexes, and under multiple experimental conditions to model genome …

We require experimental populations in which to test precision medicine interventions
before they can be translated to humans. Mouse models can provide immortal genometypes …