Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …

Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …

The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease notoriously resistant to
therapy,. This is mediated in part by a complex tumour microenvironment, low vascularity …

Itaconate has emerged as a critical immunoregulatory metabolite. Here, we examined the
therapeutic potential of itaconate in atherosclerosis. We found that both itaconate and the …

Our increased understanding of how key metabolic pathways are activated and regulated in
malignant cells has identified metabolic vulnerabilities of cancers. Translating this insight to …

Pancreatic cancer has a notoriously poor prognosis, exhibits persistent drug resistance, and
lacks a cure. Unique features of the pancreatic tumor microenvironment exacerbate …

The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating
catabolic conversions of NAD+ to NADH and anabolic production of aspartate, a key amino …

Pancreatic ductal adenocarcinoma (PDA) cells reprogram both mitochondrial and lysosomal
functions to support growth. At the same time, this causes significant dishomeostasis of free …

The incidence of pancreatic cancer is increasing in both developed and developing Nations.
In recent years, various research evidence suggested that reprogrammed metabolism may …