Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches
M Vidović, MG Rikalovic - Cells, 2022 - mdpi.com
Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …
Biochemistry, safety, pharmacological activities, and clinical applications of turmeric: a mechanistic review
RS Ahmad, MB Hussain, MT Sultan… - Evidence‐Based …, 2020 - Wiley Online Library
Turmeric (Curcuma longa L.) is a popular natural drug, traditionally used for the treatment of
a wide range of diseases. Its root, as its most popular part used for medicinal purposes …
a wide range of diseases. Its root, as its most popular part used for medicinal purposes …
Targeted exosome coating gene-chem nanocomplex as “nanoscavenger” for clearing α-synuclein and immune activation of Parkinson's disease
L Liu, Y Li, H Peng, R Liu, W Ji, Z Shi, J Shen, G Ma… - Science …, 2020 - science.org
The most critical problem in the treatment of neurodegenerative diseases is brain neuronal
protection, which can be overcome by clearing pathological substances and regulating the …
protection, which can be overcome by clearing pathological substances and regulating the …
α‐Synuclein oligomers and clinical implications for Parkinson disease
Protein aggregation within the central nervous system has been recognized as a defining
feature of neurodegenerative diseases since the early 20th century. Since that time, there …
feature of neurodegenerative diseases since the early 20th century. Since that time, there …
Curcumin modulates α-synuclein aggregation and toxicity
In human beings, Parkinson's disease (PD) is associated with the oligomerization and
amyloid formation of α-synuclein (α-Syn). The polyphenolic Asian food ingredient curcumin …
amyloid formation of α-synuclein (α-Syn). The polyphenolic Asian food ingredient curcumin …
Tau‐Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease
The failure of several Phase II/III clinical trials in Alzheimer's disease (AD) with drugs
targeting β‐amyloid accumulation in the brain fuelled an increasing interest in alternative …
targeting β‐amyloid accumulation in the brain fuelled an increasing interest in alternative …
Curcumin affords neuroprotection and inhibits α-synuclein aggregation in lipopolysaccharide-induced Parkinson's disease model
N Sharma, B Nehru - Inflammopharmacology, 2018 - Springer
Parkinson's disease (PD) pathology is characterized by the abnormal accumulation and
aggregation of the pre-synaptic protein α-synuclein in the dopaminergic neurons as Lewy …
aggregation of the pre-synaptic protein α-synuclein in the dopaminergic neurons as Lewy …
Protein folding and aggregation into amyloid: the interference by natural phenolic compounds
M Stefani, S Rigacci - International journal of molecular sciences, 2013 - mdpi.com
Amyloid aggregation is a hallmark of several degenerative diseases affecting the brain or
peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils …
peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils …
Insight into the binding mechanism of imipenem to human serum albumin by spectroscopic and computational approaches
The mechanism of interaction between imipenem and HSA was investigated by various
techniques like fluorescence, UV–vis absorbance, FRET, circular dichroism, urea …
techniques like fluorescence, UV–vis absorbance, FRET, circular dichroism, urea …