Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …

MG Savelieff, G Nam, J Kang, HJ Lee, M Lee… - Chemical …, 2018 - ACS Publications
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches

M Vidović, MG Rikalovic - Cells, 2022 - mdpi.com
Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Biochemistry, safety, pharmacological activities, and clinical applications of turmeric: a mechanistic review

RS Ahmad, MB Hussain, MT Sultan… - Evidence‐Based …, 2020 - Wiley Online Library
Turmeric (Curcuma longa L.) is a popular natural drug, traditionally used for the treatment of
a wide range of diseases. Its root, as its most popular part used for medicinal purposes …

Targeted exosome coating gene-chem nanocomplex as “nanoscavenger” for clearing α-synuclein and immune activation of Parkinson's disease

L Liu, Y Li, H Peng, R Liu, W Ji, Z Shi, J Shen, G Ma… - Science …, 2020 - science.org
The most critical problem in the treatment of neurodegenerative diseases is brain neuronal
protection, which can be overcome by clearing pathological substances and regulating the …

α‐Synuclein oligomers and clinical implications for Parkinson disease

LV Kalia, SK Kalia, PJ McLean, AM Lozano… - Annals of …, 2013 - Wiley Online Library
Protein aggregation within the central nervous system has been recognized as a defining
feature of neurodegenerative diseases since the early 20th century. Since that time, there …

Curcumin modulates α-synuclein aggregation and toxicity

PK Singh, V Kotia, D Ghosh, GM Mohite… - ACS chemical …, 2013 - ACS Publications
In human beings, Parkinson's disease (PD) is associated with the oligomerization and
amyloid formation of α-synuclein (α-Syn). The polyphenolic Asian food ingredient curcumin …

Tau‐Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease

F Panza, V Solfrizzi, D Seripa… - BioMed research …, 2016 - Wiley Online Library
The failure of several Phase II/III clinical trials in Alzheimer's disease (AD) with drugs
targeting β‐amyloid accumulation in the brain fuelled an increasing interest in alternative …

Curcumin affords neuroprotection and inhibits α-synuclein aggregation in lipopolysaccharide-induced Parkinson's disease model

N Sharma, B Nehru - Inflammopharmacology, 2018 - Springer
Parkinson's disease (PD) pathology is characterized by the abnormal accumulation and
aggregation of the pre-synaptic protein α-synuclein in the dopaminergic neurons as Lewy …

Protein folding and aggregation into amyloid: the interference by natural phenolic compounds

M Stefani, S Rigacci - International journal of molecular sciences, 2013 - mdpi.com
Amyloid aggregation is a hallmark of several degenerative diseases affecting the brain or
peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils …

Insight into the binding mechanism of imipenem to human serum albumin by spectroscopic and computational approaches

MT Rehman, H Shamsi, AU Khan - Molecular Pharmaceutics, 2014 - ACS Publications
The mechanism of interaction between imipenem and HSA was investigated by various
techniques like fluorescence, UV–vis absorbance, FRET, circular dichroism, urea …