Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are
maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic …

Hyperinsulinemic hypoglycemia (HH) is characterized by unregulated insulin release,
leading to persistently low blood glucose concentrations with lack of alternative fuels, which …

Pancreatic β cells are functionally programmed to release insulin in response to changes in
plasma glucose concentration. Insulin secretion is precisely regulated so that, under normal …

Context: Congenital hyperinsulinism (CHI) is the most common cause of persistent
hypoglycemia in neonates and infants. In medically unresponsive CHI, subtotal …

Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycmia in
neonatles and children. The inappropriate secretion of insulin by the pancreatic β-cells …

Hyperinsulinaemic hypoglycaemia (HH) is a heterogeneous condition with dysregulated
insulin secretion which persists in the presence of low blood glucose levels. It is the most …

Hyperinsulinaemic hypoglycaemia (HH) is a biochemical finding of low blood glucose levels
due to the dysregulation of insulin secretion from pancreatic β-cells. Under normal …

Introduction Sirolimus, a mammalian target of rapamycin inhibitor, has been used in
congenital hyperinsulinism (CHI) unresponsive to diazoxide and octreotide. Reported …

We have recently published on the limited effectiveness of sirolimus as a treatment option for
hypoglycaemia as a consequence of hyperinsulinism. Our data oppose the view that mTOR …

Glucose homeostasis requires appropriate and synchronous coordination of metabolic
events and hormonal activities to keep plasma glucose concentrations in a narrow range of …