Objective To investigate, by systematically reviewing the literature, whether the attention-
deficit/hyperactivity disorder (ADHD) polygenic risk score (PRS) associates with ADHD and …

There is growing appreciation that a developmental perspective is helpful in Psychiatry.
However, clinical practice and research, especially in an era of very large sample sizes …

Irritability, defined as proneness to anger that may impair an individual's functioning, is
common in youths. There has been a recent upsurge in relevant research. The authors …

Irritability is increasingly recognized as a significant clinical problem in youth. It is a criterion
for multiple diagnoses and predicts the development of a wide range of disorders. Research …

Objective Impairing emotional outbursts, defined by extreme anger or distress in response to
relatively ordinary frustrations and disappointments, impact all mental health care systems …

Young people with neurodevelopmental disorders, such as attention‐deficit hyperactivity
disorder (ADHD) and autism spectrum disorder (ASD), show high rates of mental health …

Irritability, defined as an increased proneness to anger relative to peers at the same
developmental level, 1 is linked to depression. This review first distinguishes between two …

Objective Irritability is a common and clinically important problem in children and
adolescents and a risk factor for later psychopathology and impairment. Irritability can …

Objective Irritability is a dimensional trait that manifests from early life and is a robust
transdiagnostic risk factor for psychopathology and impairment. A large, national dataset …

Early identification of attention-deficit/hyperactivity disorder (ADHD) is critical for mitigating
the many negative functional outcomes associated with its diagnosis. Because of the strong …