Exosomes are well-known key mediators of intercellular communication and contribute to
various physiological and pathological processes. Their biogenesis involves four key steps …

Abstract Dihydroceramide desaturase 1 (DEGS1) converts dihydroceramide (dhCer) to
ceramide (Cer) by inserting a C4-C5 trans (∆ 4E) double bond into the sphingoid backbone …

During oxidative stress neurons release lipids that are internalized by glia. Defects in this
coordinated process play an important role in several neurodegenerative diseases. Yet, the …

West Nile virus (WNV) is a neurotropic flavivirus transmitted by the bites of infected
mosquitoes. Severe forms of West Nile disease (WND) can curse with meningitis …

Specific membrane lipids play unique roles in (macro) autophagy. Those include
phosphatidylethanolamine, to which LC3/GABARAP autophagy proteins become covalently …

The Covid-19 pandemic driven by the SARS-CoV-2 virus continues to exert extensive
humanitarian and economic stress across the world. Although antivirals active against mild …

Sphingolipids (SL) represent a structurally diverse class of lipids that are central to cellular
physiology and neuronal development and function. Defects in the sphingolipid metabolism …

The plasma membrane of eukaryotic cells is composed of a large number of lipid species
that are laterally segregated into functional domains as well as asymmetrically distributed …

Osteoporosis is a systemic bone disease characterized by reduced bone mass and
destruction of bone microarchitecture, leading to increased bone fragility and susceptibility …

Hematopoietic stem and progenitor cell (HSPC) transplantation serves as a curative therapy
for many benign and malignant hematopoietic disorders and as a platform for gene therapy …