Cell-surface heparan sulfate proteoglycans as multifunctional integrators of signaling in cancer
Proteoglycans (PGs) represent a large proportion of the components that constitute the
extracellular matrix (ECM). They are a diverse group of glycoproteins characterized by a …
extracellular matrix (ECM). They are a diverse group of glycoproteins characterized by a …
CD44 in cancer progression: adhesion, migration and growth regulation
R Marhaba, M Zöller - Journal of molecular histology, 2004 - Springer
It is well established that the large array of functions that a tumour cell has to fulfil to settle as
a metastasis in a distant organ requires cooperative activities between the tumour and the …
a metastasis in a distant organ requires cooperative activities between the tumour and the …
Molecular mechanism of violacein-mediated human leukemia cell death
Violacein, a pigment isolated from Chromobacterium violaceum in the Amazon River,
presents diverse biologic properties and attracts interest as a consequence of its …
presents diverse biologic properties and attracts interest as a consequence of its …
[HTML][HTML] Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells
L Chen, LYW Bourguignon - Molecular Cancer, 2014 - Springer
Abstract MicroRNA-21 (miR-21) is associated with the development of solid tumors
progression including breast cancer. In this study we investigated matrix hyaluronan (HA) …
progression including breast cancer. In this study we investigated matrix hyaluronan (HA) …
[HTML][HTML] Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia
Accumulating evidence support the notion that acute myeloid leukemia (AML) is organized
in a hierarchical system, originating from a special proportion of leukemia stem cells (LSC) …
in a hierarchical system, originating from a special proportion of leukemia stem cells (LSC) …
CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia
O Fedorchenko, M Stiefelhagen… - Blood, The Journal …, 2013 - ashpublications.org
The cell-surface glycoprotein CD44 is expressed in chronic lymphocytic leukemia (CLL), but
its functional role in this disease is poorly characterized. We therefore investigated the …
its functional role in this disease is poorly characterized. We therefore investigated the …
Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks
R Huber, D Pietsch, J Günther, B Welz, N Vogt… - Cellular and molecular …, 2014 - Springer
Monocyte/macrophages are important players in orchestrating the immune response as well
as connecting innate and adaptive immunity. Myelopoiesis and monopoiesis are …
as connecting innate and adaptive immunity. Myelopoiesis and monopoiesis are …
Hyaluronan network: A driving force in cancer progression
T Karalis, SS Skandalis - American Journal of Physiology …, 2022 - journals.physiology.org
Hyaluronan is one of the most abundant macromolecules of the extracellular matrix and
regulates several physiological cell and tissue properties. However, hyaluronan has been …
regulates several physiological cell and tissue properties. However, hyaluronan has been …
Target proteins of C/EBPαp30 in AML: C/EBPαp30 enhances sumoylation of C/EBPαp42 via up-regulation of Ubc9
CCAAT/enhancer-binding protein α (C/EBPα) is a critical regulator for early myeloid
differentiation. Mutations in C/EBPα occur in 10% of patients with acute myeloid leukemia …
differentiation. Mutations in C/EBPα occur in 10% of patients with acute myeloid leukemia …
The stem cell code in oral epithelial tumorigenesis:'the cancer stem cell shift hypothesis'
Tumors of the oral cavity provide an ideal model to study various stages of epithelial tumor
progression. A group of cancer cells termed cancer stem cells (CSCs) eludes therapy …
progression. A group of cancer cells termed cancer stem cells (CSCs) eludes therapy …