More than 350 individual MYPBC3 mutations have been identified in patients with inherited
hypertrophic cardiomyopathy (HCM), thus representing 40–50% of all HCM mutations …

Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

The sarcomere is an exquisitely designed apparatus that is capable of generating force,
which in the case of the heart results in the pumping of blood throughout the body. At the …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

Diastolic dysfunction is a prominent feature of cardiac aging in both mice and humans. We
show here that 8-week treatment of old mice with the mitochondrial targeted peptide SS-31 …

Oxidative stress accompanies a wide spectrum of clinically important cardiac disorders,
including ischemia/reperfusion, diabetes mellitus, and hypertensive heart disease. Although …

Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) accelerates cardiac
contractility. However, the mechanisms by which cMyBP-C phosphorylation increases …

Cardiac myosin–binding protein-C (cMyBP-C) is a thick filament-associated protein that
seems to contribute to the regulation of cardiac contraction through interactions with either …

Heart failure (HF) is a complex disease in which cardiomyocyte injury leads to a cascade of
inflammatory and fibrosis pathway activation, thereby causing decrease in cardiac function …

Calcium dynamics is central in cardiac physiology, as the key event leading to the excitation-
contraction coupling (ECC) and relaxation processes. The primary function of Ca2+ in the …