Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

The rapid quantification of therapeutic monoclonal antibodies (mAbs) is of great significance
to their pharmacokinetics/pharmacodynamics (PK/PD) research and the personalized …

Targeted degradation of the cell-surface and extracellular proteins via the endogenous
lysosomal degradation pathways, such as lysosome-targeting chimeras (LYTACs), has …

Introduction In the field of bioconjugates, the focus on antibody–drug conjugates (ADCs)
with novel payloads beyond the traditional categories of potent cytotoxic agents is …

RNA-based therapeutics have emerged as promising approaches to modulate gene
expression and generate therapeutic proteins or antigens capable of inducing immune …

Patients receiving high-dose methotrexate (HDMTX) for malignancies are exposed to
diverse complications, including nephrotoxicity, hepatotoxicity, mucositis, myelotoxicity …

Bispecific antibodies (BisAbs) are biotherapeutics that amalgamate the specificities of two
distinct antibodies into one molecule, however, their engineering requires genetic …

Inspired by the immune system's own strategy for macrophage activation, we describe here
a simple self-assembly strategy for generating artificial immune complexes. The built-in …

In the ever-evolving landscape of cancer research, immuno-oncology stands as a beacon of
hope, offering novel avenues for treatment. This study capitalizes on the vast repository of …