Lytic polysaccharide monooxygenases: enzymes for controlled and site-specific Fenton-like chemistry
B Bissaro, VGH Eijsink - Essays in biochemistry, 2023 - portlandpress.com
The discovery of oxidative cleavage of glycosidic bonds by enzymes currently known as lytic
polysaccharide monooxygenases (LPMOs) has profoundly changed our current …
polysaccharide monooxygenases (LPMOs) has profoundly changed our current …
How do metalloproteins tame the Fenton reaction and utilize• OH radicals in constructive manners?
Conspectus This Account describes the manner whereby nature controls the Fenton-type
reaction of O–O homolysis of hydrogen peroxide and harnesses it to carry out various useful …
reaction of O–O homolysis of hydrogen peroxide and harnesses it to carry out various useful …
Kβ X-ray Emission Spectroscopy of Cu(I)-Lytic Polysaccharide Monooxygenase: Direct Observation of the Frontier Molecular Orbital for H2O2 Activation
Lytic polysaccharide monooxygenases (LPMOs) catalyze the degradation of recalcitrant
carbohydrate polysaccharide substrates. These enzymes are characterized by a …
carbohydrate polysaccharide substrates. These enzymes are characterized by a …
Fenton-like Chemistry by a Copper(I) Complex and H2O2 Relevant to Enzyme Peroxygenase C–H Hydroxylation
B Kim, MT Brueggemeyer, WJ Transue… - Journal of the …, 2023 - ACS Publications
Lytic polysaccharide monooxygenases have received significant attention as catalytic
convertors of biomass to biofuel. Recent studies suggest that its peroxygenase activity (ie …
convertors of biomass to biofuel. Recent studies suggest that its peroxygenase activity (ie …
The “life-span” of lytic polysaccharide monooxygenases (LPMOs) correlates to the number of turnovers in the reductant peroxidase reaction
Lytic polysaccharide monooxygenases (LPMOs) are monocopper enzymes that degrade the
insoluble crystalline polysaccharides cellulose and chitin. Besides the H 2 O 2 cosubstrate …
insoluble crystalline polysaccharides cellulose and chitin. Besides the H 2 O 2 cosubstrate …
Histidine oxidation in lytic polysaccharide monooxygenase
M Torbjörnsson, MM Hagemann, U Ryde… - JBIC Journal of …, 2023 - Springer
The lytic polysaccharide monooxygenases (LPMOs) comprise a super-family of copper
enzymes that boost the depolymerisation of polysaccharides by oxidatively disrupting the …
enzymes that boost the depolymerisation of polysaccharides by oxidatively disrupting the …
[PDF][PDF] Changes in active-site geometry on X-ray photoreduction of a lytic polysaccharide monooxygenase active-site copper and saccharide binding
The recently discovered lytic polysaccharide monooxygenases (LPMOs) are Cu-containing
enzymes capable of degrading polysaccharide substrates oxidatively. The generally …
enzymes capable of degrading polysaccharide substrates oxidatively. The generally …
Looking at LPMO reactions through the lens of the HRP/Amplex Red assay
AA Stepnov, VGH Eijsink - Methods in Enzymology, 2023 - Elsevier
Lytic polysaccharide monooxygenases (LPMOs) are unique redox enzymes capable of
disrupting the crystalline surfaces of industry-relevant recalcitrant polysaccharides, such as …
disrupting the crystalline surfaces of industry-relevant recalcitrant polysaccharides, such as …
A designed Copper Histidine-brace enzyme for oxidative depolymerization of polysaccharides as a model of lytic polysaccharide monooxygenase
Y Liu, KA Harnden, C Van Stappen… - Proceedings of the …, 2023 - National Acad Sciences
The “Histidine-brace”(His-brace) copper-binding site, composed of Cu (His) 2 with a
backbone amine, is found in metalloproteins with diverse functions. A primary example is …
backbone amine, is found in metalloproteins with diverse functions. A primary example is …
Protonation state of an important histidine from high resolution structures of lytic polysaccharide monooxygenases
S Banerjee, SJ Muderspach, T Tandrup, KEH Frandsen… - Biomolecules, 2022 - mdpi.com
Lytic Polysaccharide Monooxygenases (LPMOs) oxidatively cleave recalcitrant
polysaccharides. The mechanism involves (i) reduction of the Cu,(ii) polysaccharide …
polysaccharides. The mechanism involves (i) reduction of the Cu,(ii) polysaccharide …