The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …

Lipid encapsulated messenger RNA (LNP mRNA) has garnered a significant amount of
interest from the pharmaceutical industry and general public alike. This attention has been …

Microbial pathogens adapt to the stress of infection by regulating transcription, translation
and protein modification. We report that changes in gene expression in hypoxia-induced …

A common feature of ribonucleic acids (RNAs) is that they can undergo a variety of chemical
modifications. As nearly all of these chemical modifications result in an increase in the mass …

With the development of therapeutic oligonucleotides for antisense and gene therapies, the
demand for analytical methods also increases. For the analysis of complex samples, for …

A small set of ribonucleoside modifications have been found in different regions of mRNA
including the open reading frame. Accurate detection of these specific modifications is …

Mass spectrometry is a powerful analytical tool for identifying and characterizing structural
modifications to the four canonical bases in RNA, information that is lost when using …

Organisms from all domains of life invest a substantial amount of energy for the introduction
of RNA modifications into nearly all transcripts studied to date. Instrumental analysis of RNA …

The discovery of functional small noncoding RNAs (ncRNAs), such as microRNAs and small
interfering RNAs, in the control of human cellular processes has opened new avenues to …

The post‐transcriptional modification of RNA by the addition of one or more chemical groups
has been known for over 50 years. These chemical modifications, once thought to be static …