Implications and mechanism of action of gabapentin in neuropathic pain

A Kukkar, A Bali, N Singh, AS Jaggi - Archives of pharmacal research, 2013 - Springer
Gabapentin is an anti-epileptic agent but now it is also recommended as first line agent in
neuropathic pain, particularly in diabetic neuropathy and post herpetic neuralgia. α2δ-1, an …

B vitamins alleviate indices of neuropathic pain in diabetic rats

CG Jolivalt, LM Mizisin, A Nelson, JM Cunha… - European journal of …, 2009 - Elsevier
There are sporadic reports that assorted combinations of B vitamins can alleviate pain in
diabetic patients, but there is neither agreement on the relative efficacy of individual B …

Thiamine and riboflavin inhibit production of cytokines and increase the anti-inflammatory activity of a corticosteroid in a chronic model of inflammation induced by …

RR Menezes, AM Godin, FF Rodrigues… - Pharmacological …, 2017 - Elsevier
Background The effects induced by thiamine and riboflavin, isolated or in association with
corticosteroids, in models of chronic inflammation are not known. Thus, we evaluated the …

Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: a potential biomarker of efficacy

JY Xie, C Qu, A Patwardhan, MH Ossipov… - Pain, 2014 - journals.lww.com
Relief of ongoing pain may be reflected by increased dopamine efflux in the nucleus
accumbens, providing a neurochemical efficacy measure for evaluation of novel analgesics …

THC and gabapentin interactions in a mouse neuropathic pain model

N Atwal, SL Casey, VA Mitchell, CW Vaughan - Neuropharmacology, 2019 - Elsevier
Clinical studies have shown that the major psychoactive ingredient of Cannabis sativa Δ9-
tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states …

Clinical trial assessing the efficacy of gabapentin plus B complex (B1/B12) versus pregabalin for treating painful diabetic neuropathy

A Mimenza Alvarado… - Journal of Diabetes …, 2016 - Wiley Online Library
Introduction. Painful diabetic neuropathy (PDN) is a prevalent and impairing disorder. The
objective of this study was to show the efficacy and safety of gabapentin (GBP) plus complex …

Витамины группы В в лечении неврологических заболеваний

ИА Строков, ЛТ Ахмеджанова, ОА Солоха - РМЖ, 2009 - elibrary.ru
Клиницисты знают, что дефицит витаминов В1 (тиамин), В6 (пиридоксин) и В12
(кобаламин) приводит к развитию поражения периферических нервов, поэтому …

[HTML][HTML] B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats

CM Kopruszinski, RC Reis, JG Chichorro - Life sciences, 2012 - Elsevier
AIMS: There is mounting evidence that use of B vitamins can help control neuropathic pain.
This study investigated if treatment with B1, B6 and B12 vitamins, alone or in combination …

Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain

P Barragán-Iglesias, VH Oidor-Chan… - Pharmacological …, 2018 - Elsevier
Background The purpose of this study was to evaluate the participation of satellite glial cells
(SGC), microglia and astrocytes in a model of streptozotocin-induced diabetes initiated in …

Concomitant antihyperalgesic and antitumor effects of gabapentin in a murine cancer pain model

BE Brito, MA García, YM De Gouveia… - International journal of …, 2021 - mdpi.com
Cancer pain may be the consequence of physical nerve compression by a growing tumor.
We employed a murine model to study whether gabapentin was able to regulate tumor …