A structural view of SARS-CoV-2 RNA replication machinery: RNA synthesis, proofreading and final capping
The current coronavirus disease-2019 (COVID-19) pandemic is due to the novel coronavirus
SARS-CoV-2. The scientific community has mounted a strong response by accelerating …
SARS-CoV-2. The scientific community has mounted a strong response by accelerating …
Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses
Y Ma, E Frutos-Beltrán, D Kang… - Chemical Society …, 2021 - pubs.rsc.org
During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …
drug discovery culminating with the introduction of therapies able to stop human …
The 1, 2, 3-triazole 'all-in-one'ring system in drug discovery: A good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool
ABSTRACT Introduction The 1, 2, 3-triazole ring occupies an important space in medicinal
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
The human DEAD-box helicase DDX3X as a regulator of mRNA translation
CS Ryan, M Schröder - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The human DEAD-box protein DDX3X is an RNA remodelling enzyme that has been
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …
[HTML][HTML] Mechanism-based approaches of 1, 3, 4 thiadiazole scaffolds as potent enzyme inhibitors for cytotoxicity and antiviral activity
Significant progress in understanding cancer pathogenesis, it remains one of the leading
causes of death after cardiovascular diseases. Similarly viral infections have emerged from …
causes of death after cardiovascular diseases. Similarly viral infections have emerged from …
[HTML][HTML] Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection
COVID-19 is currently a highly pressing health threat and therapeutic strategies to mitigate
the infection impact are urgently needed. Characterization of the SARS-CoV-2 interactome …
the infection impact are urgently needed. Characterization of the SARS-CoV-2 interactome …
The multifaceted roles of NLRP3-modulating proteins in virus infection
The innate immune response to viruses is critical for the correct establishment of protective
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …
DDX3X suppresses the susceptibility of hindbrain lineages to medulloblastoma
DM Patmore, A Jassim, E Nathan, RJ Gilbertson… - Developmental cell, 2020 - cell.com
Summary DEAD-Box Helicase 3 X-Linked (DDX3X) is frequently mutated in the Wingless
(WNT) and Sonic hedghog (SHH) subtypes of medulloblastoma—the commonest malignant …
(WNT) and Sonic hedghog (SHH) subtypes of medulloblastoma—the commonest malignant …
A rational designed bioorthogonal surface-enhanced Raman scattering nanoprobe for quantitatively visualizing endogenous hydrogen sulfide in single living cells
Understanding the biology of gasotransmitters in living cells is of significance but remains
challenging due to largely a lack of robust molecular probes. Here, we present the facile …
challenging due to largely a lack of robust molecular probes. Here, we present the facile …
Recent advances in applying G-quadruplex for SARS-CoV-2 targeting and diagnosis: A review
The coronavirus SARS-CoV-2 has caused a health care crisis all over the world since the
end of 2019. Although vaccines and neutralizing antibodies have been developed, rapidly …
end of 2019. Although vaccines and neutralizing antibodies have been developed, rapidly …