Cancer cells are metabolically vigorous and are superior in the uptake of nutrients and in the
release of the tumor microenvironment (TME)-specific metabolites. They create an acidic …

Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …

The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids
across the membrane and is crucial for brain drug delivery and tumor growth. LAT1 forms a …

YAP and TAZ are transcriptional co-activators and function as the major effectors of the
Hippo tumor suppressor pathway, which controls cell growth, tissue homeostasis, and organ …

The SLC3A2 gene encodes for a cell-surface transmembrane protein CD98hc (4F2).
CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), y+ LAT1 (SLC7A7), y+ …

The constitutive anabolism of cancer cells not only supports proliferation but also addicts
tumor cells to a steady influx of exogenous nutrients. Limiting access to metabolic substrates …

Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …

Oncogenic RAS mutations are common in multiple myeloma (MM), an incurable malignancy
of plasma cells. However, the mechanisms of pathogenic RAS signaling in this disease …

Proteostasis requires oxidative metabolism (ATP) and mitigation of the associated damage
by glutathione, in an increasingly dysfunctional relationship with aging. SLC3A2 (4F2hc …

Malaria infection induces complex and diverse immune responses. To elucidate the
mechanisms underlying host–parasite interaction, we performed a genetic screen during …