Mitochondrial dysfunction and oxidative stress: Role in chronic kidney disease

A Srivastava, B Tomar, D Sharma, SK Rath - Life Sciences, 2023 - Elsevier
Chronic kidney disease (CKD) is associated with a variety of distinct disease processes that
permanently change the function and structure of the kidney across months or years. CKD is …

Study of MDM2 as Prognostic Biomarker in Brain-LGG Cancer and Bioactive Phytochemicals Inhibit the p53-MDM2 Pathway: A Computational Drug Development …

P Biswas, S Bibi, Q Yousafi, A Mehmood, S Saleem… - Molecules, 2023 - mdpi.com
An evaluation of the expression and predictive significance of the MDM2 gene in brain lower-
grade glioma (LGG) cancer was carried out using onco-informatics pipelines. Several …

Molecular Dynamics Simulation and Pharmacoinformatic Integrated Analysis of Bioactive Phytochemicals from Azadirachta indica (Neem) to Treat Diabetes Mellitus

A Abdullah, P Biswas, M Sahabuddin… - Journal of …, 2023 - Wiley Online Library
Diabetes mellitus is a chronic hormonal and metabolic disorder in which our body cannot
generate necessary insulin or does not act in response to it, accordingly, ensuing in …

Luteolin: A promising multifunctional natural flavonoid for human diseases

M Zhu, Y Sun, Y Su, W Guan, Y Wang… - Phytotherapy …, 2024 - Wiley Online Library
Natural products are closely associated with human health. Luteolin (LUT), a flavonoid
polyphenolic compound, is widely found in fruits, vegetables, flowers, and herbs. It is …

Ameliorative effect of aqueous avocado seed extract against chromium‐induced oxidative stress and cellular damage in rabbit kidney

HA Okail, S Anjum, NM Emam… - Food Science & …, 2024 - Wiley Online Library
The accumulation of chromium in renal tissues promotes the generation of reactive oxygen
species (ROS), leading to oxidative stress, genomic and cellular harm, and ultimately …

Caftaric Acid Ameliorates Oxidative Stress, Inflammation, and Bladder Overactivity in Rats Having Interstitial Cystitis: An In Silico Study

Saima, I Anjum, S Najm, K Barkat, HA Nafidi… - ACS …, 2023 - ACS Publications
Interstitial cystitis (IC) is the principal unwanted effect associated with the use of
cyclophosphamide (CYP). It results in increased oxidative stress, overexpression of …

Spasmolytic and uroprotective effects of apigenin by downregulation of TGF-β and iNOS pathways and upregulation of antioxidant mechanisms: in vitro and in silico …

I Anjum, A Mobashar, S Jahan, S Najm, HA Nafidi… - Pharmaceuticals, 2023 - mdpi.com
Apigenin is a phytochemical obtained from Chamomilla recutita. Its role in interstitial cystitis
is not yet known. The present study is aimed at understanding the uroprotective and …

[HTML][HTML] Caftaric Acid Ameliorates Oxidative Stress, Inflammation, and Bladder Overactivity in Rats Having Interstitial Cystitis: An In Silico Study

I Anjum, S Najm, K Barkat, HA Nafidi, YAB Jardan… - ACS …, 2023 - ncbi.nlm.nih.gov
Interstitial cystitis (IC) is the principal unwanted effect associated with the use of
cyclophosphamide (CYP). It results in increased oxidative stress, overexpression of …

[HTML][HTML] A single-cell profile reveals the transcriptional regulation responded for Abelmoschus manihot (L.) treatment in diabetic kidney disease

C Wu, H Tang, X Cui, N Li, J Fei, H Ge, L Wu, J Wu… - Phytomedicine, 2024 - Elsevier
Background Huangkui capsule (HKC), as an ethanol extract of Abelmoschus manihot (L.),
has a significant efficacy in treatment of the patients with diabetic kidney disease (DKD). The …

Identification and validation of the surface proteins FIBG, PDGF-β, and TGF-β on serum extracellular vesicles for non-invasive detection of colorectal cancer …

Z Huang, C Deng, C Ma, G He, J Tao… - … Journal of Surgery, 2024 - journals.lww.com
Objectives: The absence of non-invasive biomarkers for the early diagnosis of colorectal
cancer (CRC) has contributed to poor prognosis. Extracellular vesicles (EVs) have emerged …