Emerging evidence indicates that the detection and clearance of cancer cells via
phagocytosis induced by innate immune checkpoints play significant roles in tumor …

The cytotoxic activity of myeloid cells is regulated by a balance of signals that are transmitted
through inhibitory and activating receptors. The Cluster of Differentiation 47 (CD47) protein …

The development of targeted medicine has greatly expanded treatment options and spurred
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …

Extensive clinical and experimental evidence suggests that macrophages play a crucial role
in cancer immunotherapy. Cluster of differentiation (CD) 47, which is found on both healthy …

Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …

Antibodies as ideal therapeutic and diagnostic molecules are among the top-selling drugs
providing considerable efficacy in disease treatment, especially in cancer therapy …

Simple Summary Ovarian cancer is a highly lethal female malignancy with high rates of
advanced stage and recurrent disease. Ovarian cancer is characterized as poorly …

CD47 is ubiquitously expressed on the surface of cells and plays a critical role in self-
recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular …

For treatment and diagnosis of cancer, antibodies have proven their value and now serve as
a first line of therapy for certain cancers. A unique class of antibody fragments called …

Blockade of CD47, the “do not eat me” signal, has limited effects in solid tumors despite its
potent antitumor effects in hematopoietic malignancies. Taking advantage of the high …