Metal-based antitumor drugs play a relevant role in antiblastic chemotherapy. Cisplatin is
regarded as one of the most effective drugs, even if severe toxicities and drug resistance …

Several recent studies have identified nuclear factor-κB as a key modulator in driving
inflammation to cancers. Besides this transcription factor, essential in regulating …

We comprehensively reviewed the published scientific literature on non-steroidal anti-
inflammatory drugs (NSAIDs) and cancer and evaluated results based upon epidemiologic …

Environmental and occupational exposures to cadmium increase the risk of various cancers,
including lung cancer. The carcinogenic mechanism of cadmium, including its prevention …

Objective. Pancreatic cancer has an extremely poor prognosis and the cellular mechanisms
contributing to pancreatic cancer are relatively unknown. The goals of this review are to …

Background Cyclooxygenase-2 (COX-2) is constitutively overexpressed in a variety of
epithelial malignancies and is usually associated with a poor prognosis. COX-2-derived …

Preclinical and clinical studies have clearly shown a benefit of nonsteroidal anti-
inflammatory drug (NSAID) use in reducing cancer risk. However, the adverse …

Abstract Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin H synthase, has
been implicated in the growth and progression of a variety of human cancers. Although COX …

In addition to the well-established pathophysiological role that COX-2 plays in inflammation,
recent evidence implies that this isoform may also be involved in multiple biologic events …

Cyclooxygenase-2 (COX-2), an inducible prostaglandin synthase, is normally expressed in
parts of the kidney and brain. Aberrant COX-2 expression was first reported in colorectal …