Hydrogen isotopes are unique tools for identifying and understanding biological and
chemical processes. Hydrogen isotope labelling allows for the traceless and direct …

The distribution of adipose tissue in the body has wide-ranging and reproducible
associations with health and disease. Accumulation of adipose tissue in the upper body …

Nicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress
and has been reported to decline with aging in preclinical models, but human data are …

For several decades, there has been considerable interest in marine‐derived long chain n‐3
fatty acids (n‐3 LCPUFAs) due to their outstanding health benefits. n‐3 LCPUFAs can be …

Energy metabolism in humans is tuned to distinct sex-specific functions that potentially
reflect the unique requirements in females for gestation and lactation, whereas male …

Background Insulin resistance (IR) and the consequences of compensatory
hyperinsulinemia are pathogenic factors for a set of metabolic abnormalities, which …

Obesity is the hallmark of the metabolic syndrome and predisposes patients to the
development of major chronic metabolic diseases including type 2 diabetes mellitus …

There is a widespread acceptance in the literature that plasma nonesterified fatty acids
(NEFA), also called free fatty acids (FFA), can mediate many adverse metabolic effects, most …

OBJECTIVE Lipotoxicity and ectopic fat deposition reduce insulin signaling. It is not clear
whether excess fat deposition in nonadipose tissue arises from excessive fatty acid delivery …

Chronic overnutrition and physical inactivity are major risk factors for insulin resistance and
type 2 diabetes. Recent research indicates that overnutrition generates an increase in …