The list of drugs implicated in triggering DILE is expanding as new drugs with novel
mechanisms of action are being developed. It is important to recognize culprit drugs that …

Hypertension, a leading risk factor for cardiovascular disease, poses a significant public
health challenge globally. This article explores the multifaceted approach to hypertension …

Antihypertensive Medications - StatPearls - NCBI Bookshelf US flag An official website of the
United States government Here's how you know NIH NLM Logo Access keys NCBI Homepage …

Hydralazine, an antihypertensive agent used during pregnancy, undergoes N‐acetylation
primarily via N‐acetyltransferase 2 (NAT2) to form 3‐methyl‐1, 2, 4‐triazolo [3, 4‐a] …

Objectives: Identify the indications for initiating hydralazine therapy. Summarize the
theorized mechanism of action of hydralazine. Discuss the parameters of hydralazine …

This case describes a patient with pericardial effusion as a phenomenon of the drug‐
induced lupus erythematosus (DILE) syndrome due to hydralazine. The relevance of this …

Objective: Rare disease Background: Hydralazine is an effective antihypertensive agent but
may rarely have devastating hepatotoxic effects that are extremely variable, thus making the …

Clinical pharmacology and toxicology are considered nowadays two complementary and
indispensable medical disciplines that allowed clinicians to achieve the optimal therapeutic …

Up to 10% of systemic lupus erythematosus (SLE) cases are drug-induced; hence, they are
called drug-induced lupus syndrome (DILS). Antinuclear antibody (ANA) should be present …

Hydralazine induced lupus syndrome (HILS), a form of Drug-Induced Lupus (DIL), was first
reported in 1953. Since then, studies have shown an increasing incidence of HILS. It …