Purpose: Emerging published reports on the association between estrogen receptor 1
(ESR1) genetic variation and cancer susceptibility are inconsistent. This review and meta …

Our understanding of the intracrine (or local) regulation of estrogen and other steroid
synthesis and degradation expanded in the last decades, also thanks to recent …

Endometrial cancer (EC) and ovarian cancer are common gynaecological malignancies.
The impact of androgen action in these cancers is poorly understood; however, there is …

Candidate gene studies have reported CYP19A1 variants to be associated with endometrial
cancer and with estradiol (E2) concentrations. We analyzed 2937 single nucleotide …

Introduction Endometrial cancer is one of the most commonly diagnosed cancers in women.
Although there is a hereditary component to endometrial cancer, most cases are thought to …

Background: Endometrial cancer is a hormone-dependent cancer, and estrogens play a
relevant role in its etiology. However, little is known about the effects of environmental …

Endometrial cancer (EC) is among the most common gynecological disorders globally. As
single nucleotide polymorphisms (SNPs) play an important role in the causation of EC …

Background Aromatase inhibitor (AI) therapy is associated with musculoskeletal (MS)
toxicity, which adversely affects quality of life and therapy adherence. Our objective was to …

Background Endometrial cancer is the fourth most frequent gynecological cancer and the
most frequent type of uterine cancer. There is an increase in the incidence and mortality of …

CYP19 catalyzes the conversion of androgens to estrogens and is a critical enzyme affecting
the sex hormone milieu. In this study, we investigated the functions of CYP19A1 …