Summary (Macro) autophagy is a fundamental degradation process for macromolecules and
organelles of vital importance for cell and tissue homeostasis. Autophagy research has …

Continuous synthesis of all cellular components requires their constant turnover in order for
a cell to achieve homeostasis. To this end, eukaryotic cells are endowed with two …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy is a lysosome-dependent degradation system conserved among eukaryotes. The
mammalian Atg1 homologues, Unc-51 like kinase (ULK) 1 and 2, are multifunctional …

Macroautophagy is an evolutionarily conserved cellular process involved in the clearance of
proteins and organelles. Although the cytoplasmic machinery that orchestrates autophagy …

Mitochondria are intracellular power plants that feed most eukaryotic cells with the ATP
produced by the oxidative phosphorylation (OXPHOS). Mitochondrial energy production is …

Lysosomal storage diseases (LSDs) comprise a large group of disorders of catabolism,
mostly due to deficiency of a single glycan-cleaving hydrolase. The consequent endo …

Dysregulated proteostasis is one of the hallmarks of ageing. Damaged proteins may impair
cellular function and their accumulation may lead to tissue dysfunction and disease. This is …

The decreased ability of mature oligodendrocytes to produce myelin negatively affects
remyelination in demyelinating diseases and aging, but the underlying mechanisms are …

Cancer cachexia is a multifactorial syndrome characterized by anorexia, weight loss and
muscle wasting that impairs patients' quality of life and survival. Aim of this work was to …